软骨肉瘤化疗耐药机制

Sevaral mechanisms of chemoresistance in chondrosarcoma

软骨肉瘤在国内虽然不是高发疾病，但是软骨肉瘤发病后所造成的后果却足以引起我们的重视。手术治疗的局限性，对放化疗的不敏感，导致病人预后不良。若能克服软骨肉瘤的耐药性，使化学治疗能高效率杀灭肿瘤的同时抑制其侵袭转移的能力，病人的预后会有飞跃性的提高。找到软骨肉瘤的耐药机制是克服软骨肉瘤耐药性及改善预后的关键，因此本文就国内外对软骨肉瘤耐药机制的研究做如下综述。

Chondrosarcomas has low morbidity in China,but we should pay more attention to the results it contributed to. Patients usually have poor prognosis because of defect of surgical resection and resistance to con- ventional chemotherapy and radiotherapy. Chemotherapy is a significant method to the chondrosarcoma treatment. If we overcome the difficulty of chemoresistance, chemotherapy will kill the sarcoma cells efficiently and inhibit the capacity of metastasis and invasion. The patients will have better prognosis. Finding the mechanisms of che- moresistance in chandrosarcomas is the key, now we review sevaral recent mechanisms of chemoresistance in chondrosarcoma.