摘要
目的研究轻度认知障碍(mild cognitive impairment,MCI)患者相比于正常人(normal control,NC)大脑灰质萎缩特征随时间变化的纵向特征,探索正常人、稳定型MCI(stable MCI,SMCI)和进展型MCI(progressive MCI,PMCI)患者的大脑灰质萎缩的规律及组间差异,从而为阿尔茨海默病(Alzheimer disease,AD)临床诊断和治疗的评估提供相关的影像学参数依据。方法首先,采用VBMDARTEL方法对从ADNI(Alzheimer disease neuroimaging initiative)数据库中获取的NC、SMCI和PMCI 5年跟踪磁共振T1加权影像数据进行纵向分析处理。然后,对处理后的NC、SMCI和PMCI三组纵向跟踪数据,分别采用组内方差分析和相对首次扫描(baseline,BL)时间点数据的配对t检验,探索每组患者不同纵向跟踪时间点的大脑结构变化特征。结果得到NC、SMCI和PMCI组内大脑灰质萎缩随时间变化的结果,结果显示3组数据均出现大脑灰质的萎缩,并且萎缩区域逐步扩大,其中PMCI患者的灰质萎缩速度最快,SMCI患者次之。萎缩区域主要出现在颞叶、海马、枕叶、扣带回等。结论 MCI患者大脑灰质萎缩随时间变化特征较为明显。相对于较低转化率的SMCI,具有较高概率转化为AD患者的PMCI患者在大脑灰质的特定区域存在较明显的萎缩,从而可依据这些区域的萎缩情况进行PMCI的判别,有助于早期AD的临床诊断、干预和治疗。
Objective To investigate the longitudinal characteristics of the brain gray matter atrophy of mild cognitive impairment( MCI) patients in comparison with the normal control( NC) group over time,and further explore the differences of the brain gray matter atrophy between NC, stable MCI( SMCI) and progressive MCI( PMCI),for providing relevant imaging parameters for diagnosis and treatment evaluation.Methods Firstly,NC,SMCI,PMCI 5-year follow-up magnetic resonance T1-weighted image data obtained from the Alzheimer disease neuroimaging initiative( ADNI) were analyzed based on the improved VBMDARTEL method. Then, the processed longitudinal follow-up data of the three groups were analyzed by ANOVA, and paired t-test which was relative to the baseline time point separately to explore brain structure changes of each group at different time points. ResultsWith the time changing,gray matter atrophy appeared within the global brain gray matter in NC,PMCI and SMCI,and the atrophy regions were gradually expanding. The speed of atrophy in PMCI was the fastest,and then was SMCI. The atrophy regions mainly located in the temporal lobe,hippocampus,occipital lobe,cingulate gyrus,etc. Conclusions Our results showed that the brain gray matter changes over time were more obvious in MCI. Compared to SMCI( low probability of converting to AD),more obvious atrophy appeared in certain regions of gray matter in PMCI( high probability of converting to AD). Thus the atrophy differences between SMCI and PMCI could be the evidence to identify PMCI,and was helpful to clinical diagnosis,intervention and treatment of early AD.
出处
《北京生物医学工程》
2016年第2期117-123,共7页
Beijing Biomedical Engineering
基金
北京市自然科学基金(4122018)
首都医科大学基础临床科研合作课题(13JL04,13JL49)资助