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基于VBM-DARTEL的轻度认知障碍患者大脑灰质萎缩的5年纵向特征研究 被引量:4

Gray matter atrophy in MCI based on VBM-DARTEL:a five-year longitudinal study
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摘要 目的研究轻度认知障碍(mild cognitive impairment,MCI)患者相比于正常人(normal control,NC)大脑灰质萎缩特征随时间变化的纵向特征,探索正常人、稳定型MCI(stable MCI,SMCI)和进展型MCI(progressive MCI,PMCI)患者的大脑灰质萎缩的规律及组间差异,从而为阿尔茨海默病(Alzheimer disease,AD)临床诊断和治疗的评估提供相关的影像学参数依据。方法首先,采用VBMDARTEL方法对从ADNI(Alzheimer disease neuroimaging initiative)数据库中获取的NC、SMCI和PMCI 5年跟踪磁共振T1加权影像数据进行纵向分析处理。然后,对处理后的NC、SMCI和PMCI三组纵向跟踪数据,分别采用组内方差分析和相对首次扫描(baseline,BL)时间点数据的配对t检验,探索每组患者不同纵向跟踪时间点的大脑结构变化特征。结果得到NC、SMCI和PMCI组内大脑灰质萎缩随时间变化的结果,结果显示3组数据均出现大脑灰质的萎缩,并且萎缩区域逐步扩大,其中PMCI患者的灰质萎缩速度最快,SMCI患者次之。萎缩区域主要出现在颞叶、海马、枕叶、扣带回等。结论 MCI患者大脑灰质萎缩随时间变化特征较为明显。相对于较低转化率的SMCI,具有较高概率转化为AD患者的PMCI患者在大脑灰质的特定区域存在较明显的萎缩,从而可依据这些区域的萎缩情况进行PMCI的判别,有助于早期AD的临床诊断、干预和治疗。 Objective To investigate the longitudinal characteristics of the brain gray matter atrophy of mild cognitive impairment( MCI) patients in comparison with the normal control( NC) group over time,and further explore the differences of the brain gray matter atrophy between NC, stable MCI( SMCI) and progressive MCI( PMCI),for providing relevant imaging parameters for diagnosis and treatment evaluation.Methods Firstly,NC,SMCI,PMCI 5-year follow-up magnetic resonance T1-weighted image data obtained from the Alzheimer disease neuroimaging initiative( ADNI) were analyzed based on the improved VBMDARTEL method. Then, the processed longitudinal follow-up data of the three groups were analyzed by ANOVA, and paired t-test which was relative to the baseline time point separately to explore brain structure changes of each group at different time points. ResultsWith the time changing,gray matter atrophy appeared within the global brain gray matter in NC,PMCI and SMCI,and the atrophy regions were gradually expanding. The speed of atrophy in PMCI was the fastest,and then was SMCI. The atrophy regions mainly located in the temporal lobe,hippocampus,occipital lobe,cingulate gyrus,etc. Conclusions Our results showed that the brain gray matter changes over time were more obvious in MCI. Compared to SMCI( low probability of converting to AD),more obvious atrophy appeared in certain regions of gray matter in PMCI( high probability of converting to AD). Thus the atrophy differences between SMCI and PMCI could be the evidence to identify PMCI,and was helpful to clinical diagnosis,intervention and treatment of early AD.
出处 《北京生物医学工程》 2016年第2期117-123,共7页 Beijing Biomedical Engineering
基金 北京市自然科学基金(4122018) 首都医科大学基础临床科研合作课题(13JL04,13JL49)资助
关键词 阿尔茨海默病 轻度认知障碍 VBM-DARTEL 灰质萎缩 Alzheimer disease mild cognitive impairment VBM-DARTEL gray matter atrophy
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参考文献17

  • 1Barnes DE, Yaffe K.The projected effect of risk factor reduction on Alzheimer's disease prevalence[J]. Lancet Neurol, 2011, 10 (9) : 819-828.
  • 2Risacher SL,Shen L, West JD, et al. Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort [ J ]. Neurobiol Aging, 2010, 31(8) : 1401-1418.
  • 3Petersen RC, Roberts RO, Knopman DS, et al. Mild cognitive impairment: ten years later[ J]. Arch Neurol, 2009, 66 (12): 1447-1455.
  • 4Bell-MeGinty S, Lopez OL, Meltzer CC, et al. Differential cortical atrophy in subgroups of mild cognitive impairment [ J ]. Aroh Neurol, 2005, 62(9): 1393-1397.
  • 5Grothe M, Heinsen H, Teipel S. Longitudinal measures of eholinergie forebrain atrophy in the transition from healthy aging to Alzheime r' s disease [ J ]. Neurobiol Aging, 2013, 34 (4) : 1210-1220.
  • 6Whitwell JL, Przybelski SA, Weigand SD, et al.3D maps frommultiple MRI illustrate changing a trophy patterns as subjects progress from mild cognitive impairment to Alzheimer ' s disease [J]. Brain, 2007, 130(7) : 1777-1786.
  • 7Tondelli M, Wilcock GK, Nichelli P, et al. Structural MRI changes detectable up to ten years before clinical Alzhelmer~s disease[J]. Neurobiol Aging, 2012, 33(4) : 825.e25-36.
  • 8Park H, Yang JJ, Seo J, et al. Dimensionality reduced cortical features and their use in the classification of Alzheimer's disease and mild cognitive impairment [ J]. Neurosci Lett, 2012, 529 (2) : 123-127.
  • 9Cho Y, Seong JK, Jeong Y, ct al.Individual subject classification for Alzheimer' s disease based on incremental learning using a spatial frequency representation of cortical thickness data [ J ]. Neuroimage, 2012, 59(3): 2217-2230.
  • 10Eskildsen SF, Coup6 P, Gareia-Lorenzo D, et al. Prediction of Alzheimer' s disease in subjects with mild cognitive impairment from the ADNI cohort using patterns of cortical thinning [ J ]. Neuroimage, 2013, 65: 511-521.

二级参考文献11

  • 1Grothe M,Heinsen H,Teipel SJ. Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease[J].{H}Biological Psychiatry,2012,(09):805-813.
  • 2Blalock EM,Buechel HM,Popovic J. Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease[J].{H}Journal of Chemical Neuroanatomy,2011,(02):118-126.
  • 3Simón AM,de Maturana RL,Ricobaraza A. Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease[J].{H}Journal of Alzheimer's Disease,2009,(04):773-786.
  • 4Petrie EC,Cross DJ,Galasko D. Preclinical evidence of Alzheimer changes:convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings[J].{H}Archives of Neurology,2009,(05):632-637.
  • 5Duszczyk M,Kuszczyk M,Guridi M. In vivo hippocampal microdialysis reveals impairment of NMDA receptor-cGMP signaling in APP (SW)and APP(SW)/PS1 (L166P)Alzheimer's transgenic mice[J].{H}Neurochemistry International,2012,(07):976-980.
  • 6Braskie MN,Medina LD,Rodriguez-Agudelo Y. Increased fMRI signal with age in familial Alzheimer's disease mu tation carriers[J].{H}NEUROBIOLOGY OF AGING,2012,(02):11-21.
  • 7Freeman SH,Kandel R,Cruz L. Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease[J].{H}Journal of Neuropathology and Experimental Neurology,2008,(12):1205-1212.
  • 8Wang WX,Rajeev BW,Stromberg M. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1[J].{H}Journal of Neuroscience,2008,(05):1213-1223.
  • 9Michel Grothe,Helmut Heinsen,Stefan Teipel.Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer’s disease[J].Neurobiology of Aging.2012
  • 10吕晓萍,吕洋,吕晓民,梁喆,叶国东.老年痴呆患者76例的脑电图分析[J].中国老年学杂志,2011,31(16):3152-3153. 被引量:7

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