基于三层球模型弱直流电刺激下脑白质各向异性对电场分布的影响

Influence of the white matter anisotropy on the electric field distribution in three-concentric sphere model during tDCS

目的研究脑白质的各向异性电导率对经颅直流电刺激产生的电场分布的影响。方法依托经典三层同心球模型,通过基于有限元法的ANSYS软件建模,并求解头模型的电场强度、电流密度分布及初级皮质运动区的关键点数值。结果随着脑白质各向异性电导率的比率、空间分布不同,头模型中电场强度和电流密度的分布产生了较大区别。结论仿真结果说明脑白质各向异性对电场分布有显著影响,对临床应用有重要的借鉴意义。

Objective To investigate the influence of the anisotropic conductivity of white matter（ WM）in the brain on the distribution of the electric field during transcranial direct current stimulation（ t DCS）.Methods The head model was built based on the standard three-concentric sphere model,then the electric field,current density in the model and at the key point of the primary motor cortex area were simulated by ANSYS software based on the finite element method. Results The electric field and current density distribution of the head model were greatly varied with conductivity ratio and spatial distribution configurations.Conclusions The WM anisotropy has the great influence on the electric field distribution in the head model.The research of this paper provides important reference for t DCS in clinical applications.