核因子E2相关因子2在肝癌发生发展及治疗中作用的研究进展

Research progress on role of nuclear factor erythroid 2-related factor 2 in liver cancer occurrence, development and therapy

近年来肝癌发病率逐年上升,其发生与环境因素密切相关。氧化应激是环境性癌症的主要发病机制之一。核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)通过促进下游抗氧化基因及解毒酶基因表达,发挥抗氧化作用,可抑制肝癌发生。但最近的研究证据表明,肝癌中Nrf2处于高活性,且其抗氧化作用对癌细胞同样有保护作用。Nrf2持续活化介导的适应性抗氧化可参与肝癌细胞形成,促进癌症增殖、侵袭、血管形成,且参与肝癌的放化疗耐受性。该文对Nrf2在肝癌发生发展及治疗中的双重作用进行综述。

The incidence of liver cancer is climbing up recently, which is closely related to environmental factors. Oxidative stress is considered as a key mechanism underlying environmental-related cancers. Nuclear factor erythroid 2-related factor 2（Nrf2） is a master regulator in antioxidant defense which acts through its downstream antioxidant genes and detoxifying enzyme genes. Thus Nrf2 fights against liver cancer. However, high activity of Nrf2 in liver cancer is widely observed. Nrf2 may protect cancer cells as well. Persistent Nrf2 activation results in adaptive antioxidant response. This may participate in the initiation,proliferation, invasion and angiopoiesis of liver cancer, and meanwhile influence chemo- and radio-resistance of liver cancer cells. This review updated the dual roles of Nrf2 in liver cancer.