尿蛋白的严重程度对子痫前期患者孕周及新生儿体重的影响

Effect of severity of proteinuria on gestational week of patients with preeclampsia and neonatal weight

目的探讨重度子痫前期患者尿蛋白严重程度对孕周及新生儿体重的影响。方法回顾性分析150例重度子痫前期患者的临床资料,统计两组尿蛋白严重程度对孕周及新生儿体重的影响。结果 150例患者资料统计分析结果显示重度蛋白尿组入院时〈34孕周患者比例高于轻度组、入院及终止妊娠时孕周较轻度组小、期待治疗时间较轻度组长、24 h尿蛋白高于轻度组,差异均有统计学意义（P〈0.05）。孕28～32周活产的新生儿出生体重在轻、重度蛋白尿两组之间差异无统计学意义（P〉0.05）;在其余孕周,重度蛋白尿组新生儿出生体重〈轻度蛋白尿组,差异有统计学意义（P〈0.05）。结论尿蛋白的严重程度可作为预测子痫前期患者病情进展的重要指标之一,用于指导临床实践。

Objective To explore the effect of severity of proteinuria on gestational week of patients with severe preeclampsia and neonatal weight. Methods The clinical data of 150 patients with severe preeclampsia was analyzed retrospectively,the effects of severity of proteinuria on gestational week of patients and neonatal weight in two groups were analyzed statistically. Results Compared with mild proteinuria group,the proportion of patients less than 34 gestational weeks in severe proteinuria group was higher,the gestational weeks on admission and at the time of termination of pregnancy were less,the time of expectant treatment was longer,24-hour urine protein level was higher,there were statistically significant differences（ P〈0. 05）. There was no statistically significant difference in birth weight of neonates born during 28-32 gestational weeks between mild proteinuria group and severe proteinuria group（ P〉0. 05）; neonatal birth weight in severe proteinuria group during other gestational weeks was statistically significantly lighter than that in mild proteinuria group（ P〈0. 05）. Conclusion The severity of proteinuria can be used as an important indicator to predict disease progression of patients with preeclampsia and guide clinical practice.