外泌体在肾病诊疗中的作用

The role of exosome in the diagnosis and treatment of renal disease

随着靶向治疗技术的发展,外泌体逐渐成为疾病诊疗的重要靶点。多种细胞均可释放外泌体,它们是具有运载物质和传输信号功能的膜性囊泡,是几乎所有细胞胞间的交流媒介。外泌体广泛存在于血液、尿液等体液中,与肾脏的生理病理等方面关系密切。本综述旨在总结外泌体在肾病诊断和治疗的作用和进展,并提出将来外泌体研究、应用和发展的前景。

With the development of targeted treatment, exosome becomes one of the focuses of disease diagnosis and therapy. Exosome, released by a variety of cells, is a type of membrane vesicle with the potential of transferring substance and transmitting messages, which serves as a medium in most complex cell-cell communication. It can be found in blood, urine and other body fluid, and has a close relation with kidney physiology and pathology. This review aims to summarize the role of exosome in the diagnosis and treatment of renal disease, and provide the speculations about the research, usage and development of exosome.