摘要
研究EGCG对阿尔茨海默病(AD)模型大鼠神经组织的保护作用和脑组织PPARγmRNA表达的影响。SPF级SD大鼠40只随机分为3组:安静对照组10只,模型对照组15只,EGCG组15只。对模型对照组和EGCG组建立AD模型,后对EGCG组进行给药。6周后,分别对三组大鼠神经功能、脑组织PPARγmRNA和TNF-α、IL-6蛋白表达进行检测。结果发现EGCG组大鼠神经功能评分显著高于模型对照组,脑组织PPARγmRNA表达显著高于模型对照组,TNF-α、IL-6蛋白表达显著低于模型对照组。从而说明EGCG可以提高PPAR-γmRNA的表达,抑制炎性反应,发挥神经保护作用。
The aim of this study was to investigate the protective effects and PPARγ mRNA expression of EGCG on rats with Alzheimer disease. 40 SPF SD rats were randomly divided into three groups： control group（ n = 10）,model group（ n = 15）,EGCG group（ n = 15）. Model group and EGCG group were established Alzheimer＇s model. After six weeks,the nerve function,brain PPARγ mRNA and TNF-α,IL-6 protein expression of the three groups were detected. The results showed that the neurological score of EGCG group was significantly higher than that of model group. The expression of brain tissue PPARγ mRNA was significantly higher than that of model group. The expression of TNF-α,IL-6 protein was significantly lower than that of model group. To conclude,EGCG can increase the expression of PPAR-γ mRNA,inhibit the inflammatory response and avoid nerve injury.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2016年第4期596-600,共5页
Natural Product Research and Development
基金
河南省教育厅科学技术研究重点项目(14B890009)
