摘要
目的 利用频域光学相干断层扫描(SD-OCT)测量正常人和青光眼患者黄斑区视网膜神经节细胞层(GCL)厚度,并对测量结果进行重复性检验。方法 本研究纳入正常志愿者24例(正常对照组)、青光眼患者21例(青光眼组),随机选择受试者一侧眼进行测量。利用海德堡Spectralis SD-OCT后极部非对称性分析软件对黄斑区视网膜进行扫描,以早期糖尿病视网膜病变治疗研究标准对黄斑区进行分区,分析比较正常对照组和青光眼组黄斑各分区视网膜GCL厚度,并计算组内标准差(Sw)、变异系数(CV)和组内相关系数(ICC)。结果 正常对照组黄斑中央区GCL厚度为(12.58±2.69)μm,内环平均GCL厚度为(48.87±3.81)μm,外环平均GCL厚度为(37.28±1.75)μm,呈开口向颞侧的“马蹄形”分布;青光眼组黄斑中央区GCL厚度为(9.57±2.06)μm,内环平均GCL厚度为(34.70±9.67)μm,外环平均GCL厚度为(28.20±5.51)μm,各区视网膜GCL均较正常对照组明显变薄。正常对照组各分区GCL厚度的Sw为0.46~0.87μm,CV为0.67%~3.71%,ICC为0.904~0.977;青光眼组Sw为0.53~1.65μm,CV为1.18%~5.75%,ICC为0.833~0.993,2组均具有良好的重复性。结论 利用Spectralis SD-OCT测量视网膜黄斑区GCL厚度在正常人和青光眼患者中均具有良好的可重复性,可用于临床青光眼的检查和长期随访。
Objective To evaluate the reproducibility of macttlar ganglion cen layer (GCL) measurements with high-resolution spectral domain- optical coherence tomography (SD-OCT) in both normal people and glaucoma patients. Methods In this study, 24 normal subjects and 21 glauco- ma patients Were prospectively included. Macular GCL thickness in 9 areas defined by Early Treatment Diabetic Retinopathy Study was measured with Spectralis SD-OCT applying posterior pale asymmetry analysis pattern. Within-subject standard deviation (Sw), coefficient of variation (CV) and intraclass correlation coefficient (ICC) in normal subjects and glaucoma patients were assessed. Results In normal subjects, the GCL thick- ness in mactilar central area was 12.58~2.69μm, the average GCL thickness in inner ring area was 48.87~3.81μ m, the average GCL thickness in outer ring area was 37.28~ 1.75 μm, and the GCL thickness mapping in normal subjects was horseshoe-shaped with opening to temporal. In glauco- ma patients ,the GCL thickness in central area was 9.57~2.06 μm, the average GCL thickness in inner ring area was 34.70~9.67 μm, the average GCL thickness in outer ring area was 28.20±5.51 μm, and the GCL thickness in every macular area in glaucoma eyes was thinner than that in normal eyes (P 〈 0.001 ). For measurements of GCL thickness in normal subjects, Sw was 0.46 to 0.87 μm, CV was 0.67% to 3.71%, and ICC was 0.904 to 0.977. For measurements of GCL thickness in glaucoma patients, Sw was 0.53 to 1.65 μm, CV was 1.18% to 5.75%, and ICC was 0.833 to 0.993. Conclusion Spectralis SD-OCT had an excellent reproducibility for measurements of GCL thickness in both normal people and glaucoma patients, which is a reliable technique for evaluating longitudinal change and follow-up in glaucoma.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2016年第5期389-393,共5页
Journal of China Medical University
基金
国家自然科学基金(81200656)
辽宁省博士启动基金(20111097)
辽宁省科学技术计划(2013225303)
辽宁省自然科学基金(2013021029)