肺癌患者化疗期间白细胞减少的危险因素分析

Risk factors for chemotherapy-induced leucopenia occurrence in lung cancer

目的探讨肺癌患者化疗期间发生化疗相关性白细胞减少(CIL)的危险因素。方法采用病例对照研究的方法,回顾性收集2012年1月至2014年12月间收治的138例肺癌化疗患者,按CIL发生情况分为实验组(发生CIL)和对照组(未发生CIL),实验组90例,对照组48例。对两组患者的临床相关指标进行单因素和多因素分析。结果 138例肺癌化疗患者中,90例患者出现CIL,发生率为65.2%。两组患者的性别(P=0.437)、年龄(P=0.103)、基础疾病(P=0.176)差异无统计学意义。单因素分析显示,实验组患者的肝功能异常、治疗前白细胞降低、化疗药物相对剂量强度、肺癌分期、化疗次数与对照组差异有统计学意义(P<0.05)。多因素分析显示,治疗前白细胞减低(OR=3.494)、肺癌分期(OR=6.345)、化疗次数≥4次(OR=18.247)是发生CIL的危险因素。结论治疗前白细胞降低、肺癌分期、化疗次数≥4次是肺癌化疗患者发生CIL的危险因素。

Objective To explore the risk factors of chemotherapy-induced leucopenia（ CIL） occurrence in lung cancer patients accepting chemotherapy. Methods From January 2012 to December 2014 in Chinese People Liberation Army 169 Hospital,138 lung cancer patients accepting chemotherapy were enrolled in the study. According to whether CIL occurrence or not,they were divided into the experiment group（ n = 90） and the control group（ n = 48）. The clinical indexes were analysed by univariate and multivariate analysis between the two groups. Results Abnormal liver function,low white blood cells before treatment,relative dose intensity of chemotherapy drugs,lung cancer stagem and the number of chemotherapy were significantly different between the two groups in the univariate analysis（ P〈0. 05）. In the multivariate analysis,low white blood cells before treatment,lung cancer stage,the number of chemotherapy were significantly different between the two groups（ P〈0. 05）. Conclusion Low white blood cells before treatment,lung cancer stage,the number of chemotherapy are the independent risk factors for CIL in patients with lung cancer chemotherapy.