摘要
目的分析讨论某院肠内营养(EN)与其他药物合用的现状,分析可能发生的相互作用及不合理现象,促进临床合理用药。方法采用回顾性病例分析法,对2014年10-12月使用肠内营养制剂的患者,记录同时使用的其他药物进行分析。结果有525例患者使用肠内营养时同时使用其他药物,其中使用最多的科室为普通外科、消化内科及肾脏病科,合并用药的患者最多同时使用24种其他药物,合并使用3种以上药物的患者占33.42%。合并用药中以普通片剂最多,以胃肠道用药最多。结论 EN与其他药物会发生物理学、药剂学、药动学、药理学等方面的相互作用,导致喂养管堵塞、血药浓度下降、药物与营养物质的物理学等方面改变而影响药效。临床药师应当运用相关药学知识,协助医师制定合理治疗方案,促进临床合理用药。
Objective To analyze the current situation of EN and other drugs in our hospital,and to discuss the possible interaction and unreasonable phenomenon. Methods A retrospective case analysis was performed on patients with enteral nutrition prepaoration from October to December in 2014. Results There were 525 cases patients with enteral nutrition and other drugs,which were most used in general surgery,gastroenterology and kidney diseases. The patients using EN combined with more than 3 other drugs accounted for 33. 42%,of which the most was 24 drugs. Tablet was the most common dosage form,and the drugs were mostly used for gastrointestinal tract. Conclusion The interaction between EN and other drugs will be complex,included physics,pharmaceutics,pharmacology,pharmacokinetics. It can block the feeding pipe,decrease the concentration of drug in blood and affect the efficacy of the drugs and nutrients. Clinical pharmacists should use the relevant knowledge to help doctors promote clinical rational drug use.
出处
《东南国防医药》
2016年第2期160-164,共5页
Military Medical Journal of Southeast China
基金
南京军区南京总医院青年基金课题(2012059)
