代谢组学技术在针灸作用机制研究中的进展及展望

Prospect and Progress of the Research on the Technology of Metabolism in Acupuncture and Moxibustion

[目的]综述代谢组学技术在针灸作用机制研究中的进展。[方法]检索国内外数据库,收集近15年与针灸相关的代谢组研究,从针灸的经络与腧穴特异性研究、针灸治疗的疗效研究等方面进行综述,并对代谢组学在针灸方面应用的现状分析及展望。[结果]代谢组学是一种具有整体研究功能的组学研究方法,在针灸学机制研究中具有良好前景。尽管近15年来代谢组学研究技术及手段发展迅速,针灸代谢组学研究内容仍以动物实验研究为主,临床研究相对偏少,目前动物实验为基础的研究结论尚难以直接运用于临床。[结论]各类疾病的代谢特征将逐渐清晰,针灸临床优势病种疗效机制研究与代谢组学技术的结合具有广阔的前景,但研究策略还有待进一步探索及完善。

Objective] Metabolomics is a genomics research methods, has good prospects in the study of mechanisms of acupuncture. In this paper, the progress of the research on the mechanism of the action of metabolism in the mechanism of acupuncture and moxibustion were reviewed. [Methods] Retrieve acupuncture mechanism studies,which use metabolic technology in nearly 15 years, and to summarize. [Results]Nearly 15 years metabolomics research techniques and tools developed rapidly. But the acupuncture metabomoic studies were still based on the research of animal experiments mainly, relative clinical research less. [Conclusion] With the deepening development of metabolomics studies, the metabolic characteristics of various diseases will gradually clear. Acupuncture clinical mechanisms research combined with metabolomics technology will have broader prospects. But the research strategy of metabololic technology on acupuncture clinical efficacy is yet to be further explored and improved.