雌三醇及胎盘催乳素检测对胎儿生长受限的意义

Effect of estriol and placenta prolactin on fetal growth

目的探讨血清雌三醇和胎盘催乳素水平对胎儿生长发育的意义,为临床提高优生优育率提供理论依据。方法根据胎儿发育是否正常将2014年8月至2015年2月该院产科收治的孕妇分为两组。胎儿生长受限的孕妇为观察组(n=59),胎儿发育正常的孕妇为对照组(n=256),检测两组孕妇的血清雌三醇和胎盘催乳素水平,并对获得的数据进行统计学分析。结果观察组孕妇血清雌三醇水平为(13.36±2.57)ng/mL,对照组为(21.34±3.48)ng/mL,观察组明显低于对照组(t=16.593,P=0.000);观察组孕妇血清胎盘泌乳素水平为(3.28±0.84)ng/mL,对照组为(5.27±1.24)ng/mL,观察组明显低于对照组(t=1.712,P=0.000)。59例观察组血清雌三醇检测阳性率为40.68%(24/59),血清胎盘泌乳素检测阳性率为37.29%(22/59),血清雌三醇和胎盘泌乳素联合检测阳性率为71.19%(42/59)。结论联合检测孕妇血清雌三醇和胎盘催乳素水平可以对胎儿胎盘功能进行评估,对血清雌三醇和胎盘催乳素水平低下的孕妇应警惕是否存在胎儿生长受限,提高了胎儿生长受限的诊断准确率。

Objective To discuss the determination of estriol and placenta prolactin levels for fetal growth and development and provide theoretical basis for doctors to improve the rate of eugenic and superior nurture.Methods The pregnant women treated in the hospital from August 2014 and February 2015 were divided into two groups：pregnant women with fetal growth restriction were as the observation group（n=59）,who with normal fetal development were as control group（n=256）.Estriol and placenta prolactin levels of two groups tested,and the data obtained were statistically analyzed.Results Estriol level of the observation group was（13.36±2.57）ng/mL,which of the control group was（21.34±3.48）ng/mL,and the level of the observation group was lower than the control group significantly（P〈0.05）.Placenta prolactin concentration of the observation group was（3.28±0.84）ng/mL,taht of the control group was（5.27±1.24）ng/mL,and the level of the observation group was lower than the control group significantly（P〈0.05）.Estriol positive rate of observation group was 40.68%（24/59）,placenta prolactin positive rate was 37.29%（22/59）,and the positive rate of combined detection was 71.19%（42/59）.Conclusion Examination the estriol and placenta prolactin levels of pregnant female can evaluate fetal placental function.