全血γ-干扰素释放试验在结核诊断中的应用价值

Diagnostic Value of Whole Blood Interferon-γ Release Assays in Tuberculosis

目的:评价全血γ-干扰素释放试验在结核病中的诊断价值。方法:将173例疑似结核病患者分为临床明确诊断肺结核63例(肺结核组)、肺外结核43例(肺外结核组)、排除结核67例(非结核组),观察各组γ-干扰素释放试验阳性率。结果:肺结核组、肺外结核组阳性率分别为85.7%(54/63)和88.4%(38/43),显著高于非结核组11.9%(8/67)(P<0.01);诊断灵敏度为86.8%,特异度为88.1%。结论:全血γ-干扰素释放试验具有较高灵敏度和特异度,可用于肺结核及肺外结核的辅助诊断,适合临床推广使用。

Objective： To evaluate the diagnostic value of whole blood interferon-γ release assays（IGRA） in tu-berculosis. Methods： In the 173 patients with suspected tuberculosis, 63 cases were definitely diagnosed with pul-monary tuberculosis（pulmonary tuberculosis group）, 43 cases were definitely diagnosed with extra-pulmonary tuber-culosis（extra-pulmonary tuberculosis group）, and 67 cases were diagnosed with non-tuberculosis（non-tuberculosisgroup）, the positive rate of IGRA in each group was observed. Results： The positive rate of pulmonary tuberculo-sis group and extra-pulmonary tuberculosis group was 85.7%（54/63） and 88.4%（38/43） respectively, which wassignificantly higher than the non-tuberculosis group 11.9%（8/67）（P〈0.01）. The sensitivity was 86.8%, the specifici-ty was 88.1%. Conclusion： IGRA has high sensitivity and specificity, and can be used for aided diagnosis of pul-monary tuberculosis and extra-pulmonary tuberculosis, and is applicable for clinical popularization.