摘要
目的:评价全血γ-干扰素释放试验在结核病中的诊断价值。方法:将173例疑似结核病患者分为临床明确诊断肺结核63例(肺结核组)、肺外结核43例(肺外结核组)、排除结核67例(非结核组),观察各组γ-干扰素释放试验阳性率。结果:肺结核组、肺外结核组阳性率分别为85.7%(54/63)和88.4%(38/43),显著高于非结核组11.9%(8/67)(P<0.01);诊断灵敏度为86.8%,特异度为88.1%。结论:全血γ-干扰素释放试验具有较高灵敏度和特异度,可用于肺结核及肺外结核的辅助诊断,适合临床推广使用。
Objective: To evaluate the diagnostic value of whole blood interferon-γ release assays(IGRA) in tu-berculosis. Methods: In the 173 patients with suspected tuberculosis, 63 cases were definitely diagnosed with pul-monary tuberculosis(pulmonary tuberculosis group), 43 cases were definitely diagnosed with extra-pulmonary tuber-culosis(extra-pulmonary tuberculosis group), and 67 cases were diagnosed with non-tuberculosis(non-tuberculosisgroup), the positive rate of IGRA in each group was observed. Results: The positive rate of pulmonary tuberculo-sis group and extra-pulmonary tuberculosis group was 85.7%(54/63) and 88.4%(38/43) respectively, which wassignificantly higher than the non-tuberculosis group 11.9%(8/67)(P〈0.01). The sensitivity was 86.8%, the specifici-ty was 88.1%. Conclusion: IGRA has high sensitivity and specificity, and can be used for aided diagnosis of pul-monary tuberculosis and extra-pulmonary tuberculosis, and is applicable for clinical popularization.
出处
《生物技术通讯》
CAS
2016年第2期260-262,共3页
Letters in Biotechnology
关键词
Γ-干扰素释放试验
肺结核
肺外结核
诊断
interferon-γ release assays
pulmonary tuberculosis
extra-pulmonary tuberculosis
diagnosis