用纳米传感器诊断早期肺癌的研究进展

Early Diagnosis of Lung Cancer Using Nano-Nose

肺癌是世界范围内造成死亡的恶性肿瘤之一。早期识别不仅有助于检测原发癌,而且能监测肿瘤发展进程以评估风险。目前可用的诊断方法昂贵或具有侵入性,并不适于普遍筛查。非侵入性诊断技术用于监测癌症的发展仍是一个难题。基于呼气生物标志物的挥发性化合物(VOC)可用于分析患者的呼吸。本文回顾了各种VOC分析方法,包括使用最新的金纳米粒子检测VOC。该技术适于早期发现肺癌,高度准确,相对容易操作,显示出作为一种非侵入性和具有成本效益的诊断技术的巨大潜力。

Lung cancer is the most common cause of cancer-related death worldwide. Early detection not onlyhelps in indentification of primary cancer, but also in monitoring its secondaries; which creates a need for easilyapplicable tests to screen individuals at risk. The currently available diagnostic methods are expensive or invasive,and are not suitable for general screening purposes. It is still a challenge for developing non-invasive diagnostictechniques for early detection of cancer before it progresses to its later stages. A detailed review of the variousscreening methods, including breath analysis of volatile organic compounds（VOC） using gold nanoparticles, werestudied here. This technique,which is highly accurate and is relatively easy to operate, shows a great potential inbeing an non-invasive and cost-effective diagnostic technique for early identification of lung cancer.