瞬时弹性成像系统在非酒精性脂肪性肝病中的诊断价值及其与中医分型的关系

The diagnostic value of fibroscan in nonalcoholic fatty liver disease and relationship with TCM differentiation

目的:探讨瞬时弹性成像系统(Fibroscan)在非酒精性脂肪性肝病(NAFLD)中的诊断价值及其与中医分型的关系。方法:选择通过CT确诊的NAFLD的患者共64例,另外设健康对照50例,采用Fibroscan、CT肝/脾比值进行诊断比较,探讨Fibroscan在非酒精性脂肪性肝病中的诊断价值及其与中医分型的关系。结果:Fibroscan在诊断获得了最高的诊断效能,其灵敏度81.25%、特异性85.29%、阳性预测值91.22%、阴性预测值70.73%、约登指数0.66、ROC曲线下面积为0.78,并证明中医虚证患者Fibroscan的检测值大于实证患者[(269.32±33.98)vs(228.44±31.05),t=4.093,P=0.031]。结论:Fibroscan在NAFLD中的诊断效能较好,是定量诊断脂肪肝的可靠技术,与目前公认的CT诊断技术具有可比性,且中医虚实证型的Fibroscan检测值差异有显著性意义。

Objective：To investigate the diagnostic value of fibroscan in nonalcoholic fatty liver disease and relationship with TCM differentiation.Methods：sixty four cases with nonalcoholic fatty liver disease diagnosed by CT and 50 cases of healthy volunteers,as the control group were all selected.Fibroscan,CT and liver/spleen ratio were used for diagnosis and comparison.Results;FibroScan has the highest diagnostic efficiency in the diagnosis,the sensitivity was 81.25%,specificity 85.29%,positive predictive value 91.22%,negative predictive value 70.73%,Youden index 0.66 and the area under the ROC curve was 0.78.At the same time,the detection value of Fibroscan in patients with deficiency syndrome is greater than excess syndrome（269.32 ±33.98 vs 228.44 ±31.05,t = 4.093,P =0.031） Conclusion.- Fibroscan had better diagnostic efficiency in NAFLD than CT,which provides new ideas for clinical diagnosis on NAFLD.