乳腺导管内癌伴微浸润临床病理特点分析

Analysis of the clinical characteristics of breast ductal carcinoma in situ with microinvasion

目的探讨乳腺导管内癌伴微浸润(DCIS-MI)患者的临床病理特点。方法回顾性分析收治的37例乳腺导管内癌(DCIS)和64例DCIS-MI患者的临床病理资料,随机抽取乳腺浸润性导管癌(IDC)73例做对照研究。结果在组织学分级和腋淋巴结转移特征中,DCIS-MI组明显高于DCIS组而显著低于IDC组,差异有统计学意义(P<0.05);在年龄、肿瘤大小、雌激素受体(ER)、孕激素受体(PR)及人表皮生长因子受体-2(Cerb B-2)阳性表达情况方面,DCIS-MI、DCIS和IDC 3组间比较差异无统计学意义(P>0.05);在Ki-67增殖方面,DCIS组中Ki-67≥14%所占比例明显低于DCIS-MI,差异有统计学意义(P<0.05),而DCIS-MI组与IDC组间比较差异统计学意义(P>0.05)。结论 DCIS-MI的临床病理特征有别于DCIS,而与IDC较为相似,对于确诊的DCIS-MI患者,应遵循IDC的诊疗指南予以诊治。

Objective To explore the clinical characteristics of breast ductal carcinoma in situ with microinvasion（ DCIS-MI）. Methods The clinicopathologic data of 37 patients with DCIS and 64 patients with DCIS- MI were retrospectively analyzed,using73 patients with IDC as control. Results In the histological grade and axillary lymph node characteristics,DCIS- MI group was significantly higher than DCIS,while lower than the IDC group（ P〈0. 05）. In terms of age,tumor size,the positive rates of estrogen receptor,progesterone receptor and HER- 2,there were no statistic difference between DCIS- MI,DCIS and IDC（ P〉0. 05）. In terms of Ki- 67 proliferation,the Ki- 67 was greater than 14% in DCIS,which was significantly lower than the DCIS- MI group（ P〈0. 05）. There were no statistic difference between DCIS- MI and IDC（ P〉0. 05）. Conclusions The clinical characteristics of DCIS- MI was differ from DCIS,but was similar to IDC. The IDC treatment guidelines should be used to diagnose the DCIS- MI patients.