膳食中钙摄入量与脑卒中发病风险的Meta分析

The relationship between calcium intake and the risk of stroke: a meta- analysis

目的系统评价膳食中钙的摄入量与脑卒中发病风险的关系。方法检索Pubmed、Embase、Cochrane Library和ISI web of knowledge数据库,纳入评价膳食中钙的摄入量与脑卒中发病关系的研究,采用RevMan 5.3软件进行数据分析。结果共纳入11个研究对象,低到中等剂量的膳食钙摄入量（〈700 mg/d）,与脑卒中的发病呈负相关性,增加钙摄入量对脑卒中发病具有保护作用,其相对危险度（RR）为0.82、95%CI为0.76~0.88）,差异有统计学意义（P〈0.05）;高剂量膳食钙摄入量（≥700 mg/d）,与脑卒中发病呈正相关性（P〈0.05）,增加钙摄入量会加大脑卒中发病风险,其RR为1.03、95%CI为1.01~1.06,其差异有统计学意义（P〈0.05）。在亚洲人群中,增加钙摄入量对脑卒中发病具有保护作用,其RR为0.78、95%、95%CI为0.7~0.87,差异有统计学意义（P〈0.05）。结论低到中等剂量的膳食钙摄入量人群或在亚洲人群中,增加钙的膳食摄入量可以降低脑卒中的发病风险。

Objective To systematic evaluate the relationship between calcium intake and the risk of stroke. Methods The Pub med,Embase,Cochrane Library and ISI web of knowledge databases were searched,including the studies which evaluated the relationship between dietary calcium intake and stroke. Rev Man5. 3 software was used for data analysis. Results Eleven research subjects were selected. Meta- analysis showed that low and moderate doses of dietary calcium intake（〈700 mg / d）,were negatively correlated with the incidence of stroke. Increased calcium intake has a protective effect against stroke; the relative risk was 0. 82,95% CI was0. 76- 0. 88. High doses of dietary calcium intake（ ≥700 mg / d） was positively associated with stroke,the relative risk was 1. 03,95%CI was 1. 01- 1. 06. The results were statistically significant. In Asian populations,increasing calcium intake is a protective effect against stroke respectively; the relative risk was 0. 78,95% CI was 0. 71- 0. 87. Conclusions Increasing dietary calcium intake may reduce the risk of stroke in the crowd or Asian populations who have low and moderate doses of dietary calcium intake.