中效胰岛素联合糖适平与预混胰岛素治疗2型糖尿病临床效果研究

The Comparison of Intermediate-acting Insulincombined with Gliquidone with the Premixed Insulinin Treatment of Type 2 Diabetes Mellitus

目的研究预混胰岛素血糖控制不佳的2型糖尿病患者改为糖适平与中效胰岛素联合降糖的效果。方法选取我院收治的56例2型糖尿病患者,将其随机分为观察组以及对照组,观察组采用中效胰岛素联合糖适平治疗,对照组采用早晚两次注射预混胰岛素方式治疗,比较两组治疗后第5天患者的空腹血糖、平均餐后血糖、胰岛素用量及低血糖发生情况。结果治疗后5d,观察组患者的空腹血糖、平均餐后2小时血糖均明显低于对照组,治疗后2个月复查糖化血红蛋白水平观察组明显低于对照组,组间比较差异有统计学意义(P<0.05),两组胰岛素用量比较差异无统计学意义(P>0.05),两组均出现1例低血糖。结论中效胰岛素可以明显改善空腹血糖,但对餐后血糖控制欠佳者,联合糖适平治疗可以很好地克服这一问题,早晚两针中效胰岛素联合口服糖适平治疗降糖效果优于预混胰岛素治疗。

Objective To explore the curative effect of intermediate-acting insulincombined with gliquidonein treatment of type 2 diabetes mellitus when blood sugar was not in well control using the premixed insulin.Methods A total of 56 patients with type 2 diabetes in our hospital were randomly divided into observation group and control group. The observation group used intermediate-acting insulin combine with gliguidone. Control group received premixed insulin injection treatment for two times in the morning and evening. Fasting glucose level,average postprandial blood glucose,insulin dosage and occurrence of hypoglycaemia were compared 5 days after treatment in two groups. Results Five days after treatment,average fasting blood glucose,blood sugar 2hours postprandialin the observation group were significantly lower than that incontrol group（ P〈0. 05）. 2months after treatment,Hb A1 c level of observation group was significantly lower than that in control group（ P〈0. 05）. Insulin dosage had no significant difference between groups（ P〉0. 05）,both groups had only one case of hypoglycemia. Conclusion Effect ofintermediate-acting insulin can obviously improve the fasting glucose but poor of postprandial blood glucose control. Gliquidoneis a good choice to overcome this problem. Intermediateacting insulin combined with gliquidonein the treatment of type 2 diabetes mellitus used in morning and evening separately is more effective than using premixed insulin.