联合检测多肿瘤标志物在胰腺癌诊断中的意义

Significance of Combined Detection of Tumor Markers in the Diagnosis of Pancreatic Cancer

目的探讨四种血清肿瘤标志物CEA、CA19-9、CA242及CA50联合检测在胰腺癌诊断中的意义。方法检测28例胰腺癌患者以及35例健康体检者四种肿瘤标志物的水平,并对结果进行分析。结果胰腺癌患者血清中CEA、CA19-9、CA242与CA50的含量显著高于正常对照组,两者比较差异有统计学意义(P<0.01)。单项检测时CEA、CA19-9、CA242与CA50的阳性率分别为60.71%、71.42%、64.29%和53.57%,联合检测时阳性率为92.86%。结论 CEA、CA19-9、CA242与CA50对胰腺癌诊断有一定意义,四项联合检测可提高其诊断率,具有重要的临床意义。

Objective To explore the value of combined detection of CEA,CA19-9,CA242 and CA 50 in the diagnosis of pancreatic cancer. Methods The serum levels of CEA,CA19-9,CA242 and CA 50 in 28 cases of patients with pancreatic cancer and 35 healthy controls were detected,and the results were analyzed. Results The serum levels of CEA,CA19-9,CA242 and CA 50 in patients with pancreatic cancer were significantly higher that that of healthy controls（ P〈0. 05）. The positive rate CEA,CA19-9,CA242 and CA 50 with individual detection was 60. 71%,71. 42%,64. 29% and 53. 57% respectively. The positive rate of combined detection of four markers was 92. 86%. Conclusion The detection of CEA,CA19-9,CA242 and CA 50 have clinical significance in diagnosis of pancreatic cancer,can combined detection of four tumor markers could improve the diagnostic efficacy.