散结消癖汤治疗乳腺增生病临床研究

Clinical Research on Sanjie Decoction in Treatment of Cyclomastopathy

目的观察散结消癖汤治疗乳腺增生病的临床疗效并探讨其作用机制。方法将60例乳腺增生病患者随机分为治疗组和对照组,每组30例。治疗组采用散结消癖汤治疗,于经前1周开始服药,7d为1疗程;对照组采用乳癖消片治疗,每日3次口服,每次6片,治疗1个月为1疗程。两组均连续治疗3个月经周期后评定疗效。结果治疗组总有效率明显优于对照组(P<0.05);治疗后两组血清雌二醇(E2)均呈下降趋势,治疗组下降更明显,与治疗前相比较有显著性差异(P<0.05),与对照组比较有显著性差异(P<0.05);治疗后两组孕酮(P)均呈升高趋势,治疗组升高更明显,与治疗前相比较,有显著性差异(P<0.05),与对照组比较,有显著性差异(P<0.05)。结论散结消癖汤治疗乳腺增生病疗效明确,其作用机理可能与调节体内紊乱的性激素水平、恢复血清中雌二醇与孕酮含量密切相关。

Objective To observe the clinical efficacy of Sanjie decoction on cyclomastopathy and explore its mechanism of action.Methods 60 cases of cyclomastopathy were randomly divided into treatment group and control group,30 cases in each group. Treatment group received oral Sanjie decoction,started from 1 week before menstuation,7d for a course of treatment; control group received oral Rupixiao,3 times a day,6 pill a time,1month for a course of treatment. After continuous treating for 3 menstrual cycles,efficacies of both groups were evaluated. Results The total effective rate of treatment group was obviously higher than control group（ P〈0. 05）; after treatment,serum estradiol（ E2） in treatment group decreased more significantly,compared with before treatment,there was a significant difference（ P〈0.05）,compared with control group,there was a significant difference（ P〈0. 05）; after treatment,progesterone showed a rising trend,treatment group increased more significantly than before treatment with significant difference（ P〈0. 05）,compared with control group,there was a significant difference（ P〈0. 05）. Conclusion Sanjie decoction has a clear efficacy on cyclomastopathy,its mechanism of action may be closely related to regulating hormone levels and recoverying the content of estradiol and progesterone in serum.