帕金森患者视网膜神经纤维层与神经节细胞复合体的改变

Measurement of retinal nerve fiber layer and ganglion cell complex thickness in Parkinson 's disease through RTVue OCT

目的:观察帕金森患者视网膜神经纤维层厚度(peripapillary retinal nerve fiber layer thickness,pRNFL)及黄斑区神经节细胞复合体(ganglion cell complex,GCC)厚度的变化特点。方法:选取2014-07/2015-05北京天坛医院收治的原发性帕金森病(Parkinson’s disease,PD)患者40例80眼,正常对照组30例60眼,使用频域相干光学断层扫描(optic coherence tomography,OCT)对所有受试者进行检查,分别测量眼底pRNFL和GCC厚度。用独立样本t检验比较帕金森组与正常对照组之间各个象限pRNFL厚度的差异,并分析帕金森组的pRNFL厚度与GCC厚度(包括Avg、Sup和Inf厚度)的相关性。结果:帕金森组与正常对照组比较,pRNFL的上方颞侧(ST)、上方鼻侧(SN)、下方鼻侧(IN)、颞侧上方(TU)、下方颞侧(IT)、颞侧下方(TL)象限、pRNFL上方厚度(Sup)、下方厚度(Inf)和平均厚度(Avg)均具有统计学差异(P<0.05);帕金森组GCC厚度与正常对照组相比,平均厚度、上方和下方厚度均具有统计学差异(P<0.05);并与pRNFL均呈明显正相关(平均:r=0.743,P=0.01;上方:r=0.689,P=0.01;下方:r=0.693,P=0.01)。结论:帕金森患者pRNFL厚度及GCC厚度均较正常人群明显变薄,两者呈正相关。

AIM ： To investigate the morphology changes of peripapillary retinal nerve fiber layer（ pRNFL） and macular ganglion cell complex（ GCC） in patients with Parkinson ＇s disease.METHODS： Eighty eyes in 40 patients with Parkinson＇s disease（ PD） treated in Beijing Tian Tan Hospital fromJuly 2014 to M ay 2015 and 60 normal eyes in 30 patients were controlled in the study. Each section of pRNFL thickness and GCC thickness were measured by optic coherence tomography（ OCT）. The correlation between pRNFL and GCC of Parkinson ＇s disease group,and the difference of pRNFL and GCC between the Parkinson ＇s disease group and normal group were evaluated and analyzed. RESULTS： Compared with normal group,the pRNFL thickness of superior temporal（ ST）,superior nasal（ SN）,inferior nasal（ IN）, temporal upper（ TU）, inferior temporal（ IT）,temporal lower（ TL）,average,superior and inferior section significantly decreased in Parkinson＇s disease group（ P〈0. 05）. The GCC thickness of average,superior and inferior significantly decreased in theParkinson＇s disease group compared with normal group（ P〈0. 05）. The positive correlations were seen between the pRNFL thickness and the GCC thickness of average,superior,inferior respectively（ Avg： r = 0. 743,P = 0. 01;Sup： r = 0. 689,P = 0. 01; Inf： r = 0. 693,P = 0. 01）.CONCLUSION： The pRNFL thickness and GCC thinckness are significantly thinner in patients with Parkinson ＇s disease than those in the normal controls. Average,superior,inferior pRNFL thickness is positively correlated to average,superior,inferior GCC thickness respectively in Parkinson＇s disease group.