2型DR患者血小板平均体积和中性粒细胞/淋巴细胞比值检测的临床意义

Clinical significance of mean platelet volume and neutrophil-to-lymphocyte ratio in patients with diabetic retinopathy

目的:研究血小板平均体积(mean platelet volume,MPV)、中性粒细胞/淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)与2型糖尿病患者发生视网膜病变(diabetic retinopathy,DR)的关系。方法:回顾性分析2013-02/2015-07来我院就诊的2型糖尿病患者的病历资料,从中提取MPV和NLR等指标。选取96名健康体检人群作为对照组。采用Logistic回归分析MPV、NLR与2型糖尿病患者发生DR的关系。结果:共有379例2型糖尿病患者纳入研究,其中328例无DR,51例102眼有DR。2型糖尿病患者的MPV和NLR水平较健康个体明显增高。发生DR的2型糖尿病患者的MPV和NLR较未发生DR的糖尿病患者明显增高。在校正了病程、高血压等因素后,MPV>10fl和NLR>2.6仍然与DR独立相关。结论:MPV增高和NLR增高与DR的发生独立相关。

AIM ： To investigate the relation of mean platelet volume（ MPV）,neutrophil- to- lymphocyte ratio（ NLR） with diabetic retinopathy（ DR） in patient with type 2 diabetes mellitus. METHODS： Medical records of patients with type 2diabetes mellitus admitted to our hospital fromFebruary2013 to July 2015 were retrospectively reviewed. Their clinical characteristics, such as M PV and NLR, were extracted. Ninety- six healthy individuals were set as a control. The relation of M PV,NLR with DR were analyzed using logistic regression model.RESULTS： A total of 379 patients with type 2 diabetes mellitus were included in this study. Among these patients,DR was observed in 51 patients（ 102 eyes） with DR and 328 patients were without DR. Patients with type 2diabetes mellitus had significantly higher M PV and NLR,compared with healthy controls. Among patients with type 2 diabetes mellitus, the patients with DR had significantly higher M PV and NLR than the patients without DR. After confounders such as disease duration and hypertension were adjusted,M PV 10 fland NLR 2. 6were independently associated with DR. CONCLUSION： Increased MPV and NLR areindependently associated with DR. Further cohort studies are needed to verify whether M PV and NLR are independent risk factors for DR.