不同时期口腔种植修复患者血清CRP与尿脱氧吡啶啉含量变化与相关性

Study on Changes and Correlation of Serum CRP and Urinary DPd Content in Patients at Different Stages of Oral Implant Repair

目的:测定不同时期(术前1d、术后1月、术后半年)口腔种植修复患者血清CRP与尿脱氧吡啶啉含量,探讨其含量变化规律及上述两的检测指标的相关性。方法:收集接受单颗人工种植牙修复的患者86例,并符合本实验纳入标准。将上述患者分别于术前1d,术后1个月、术后6个月进行血清CRP及尿DPd的检测,所得数据设定为A1组、A2组、A3组。结果:术后1月血清CRP较术前1d所测得的血清CRP有明显升高,术后半年所测得血清CRP则呈现回落趋势(P<0.05),3组总体均数之间存在统计学差异,组间比较,术后1月血清CRP数据与另外两组存在明显统计学差异(P<0.05),术后半年血清CRP数据虽高于术前1d组数据,但两者无统计学意义(P>0.05)。对于术前1d、术后1月和术后半年尿DPd数据进行统计学分析,后两者均高于术前1d尿DPd,其中以术后1月组数据最高(P<0.05),3组总体均数之间存在统计学差异,组间比较,术日术前组数据与术后1月和术后半年组均存在显著差异(P<0.05),术后两组尿DPd数据不存在统计学差异(P>0.05)。实验组不同时期检测到的血清CRP和尿DPd数据经统计学分析呈正相关。结论:在口腔种植修复过程中,牙槽骨吸收改建的活跃期,血清CRP与尿DPd含量会出现升高,且两者之间存在明显的相关性。血清CRP与尿DPd可以初步探讨作为反映牙槽骨吸收改建的检测指标。

Objective：To study the changes and correlation of serum CRP and urine DPd content for different periods（1day before operation,1month after operation,and six months after operation）.Methods：Totally 86 cases of implant restoration in patients between 25-45 years old,without periodontitis and chronic disease,were enrolled in the study.The serum CRP and urine DPd of the patients 1day before operation（A1group）,1month after the operation（A2group）and half year after the operation（A3group）were collected.Results：Compared with A1 group,serum CRP in A2 group was significantly increased while in A3 group showed a downward trend（P〈0.05）.The serum CRP level in A2 group was significantly higher than the other two groups（P〈0.05）.Though the serum CRP level in A3 group was higher than A1 group,there was no statistical significance（P〉0.05）.As compared the levels of urinary DPd,A1 group was significant lower than A2 and A3groups and the data of A2 group was the highest（P〈0.05）.There was statistical difference among three groups of the overall mean.Serum CRP was positively correlation with urinary DPd by statistical analysis（P〈0.001）.Conclusion：Serum CRP and urine DPd content would increase in the active stage of alveolar bone remodeling during the implant restoration process.There was a significant correlation between two indices.Serum CRP and urinary DPd could be regarded as an index reflecting alveolar bone resorption and remodeling.