肺保护性通气策略在重症新生儿呼吸窘迫综合征中的应用

Application of Lung Protective Ventilation Strategy in Severe Neonatal Respiratory Distress Syndrome

目的探讨肺保护性通气策略(LPSV)在重症新生儿呼吸窘迫综合征(NRDS)中的应用效果。方法需机械通气治疗的51例NRDS随机分成两组,观察组25例,采用LPSV;对照组26例,采用传统机械通气方式。对两组呼吸机参数、并发症及住院时间等进行对比分析。结果两组吸气峰压(PIP)、呼气末正压(PEEP)和平均气道压(MAP)差异有统计学意义(P<0.05)。呼吸机相关性肺损伤(VALI)、住院时间差异有统计学意义(P<0.05)。结论 LPSV能减少VALI的发生率,缩短住院时间。

Objective To investigate the therapeutic effect of lung protective strategies of ventilation（LPSV） in neonatal respiratory distress syndrome（NRDS）. Methods 51 cases of severe NRDS treated by mechanical ventilation were divided into two groups randomly. The observation group were 25 cases applied with LPSV and the control group were 26 cases applied with conventional mechanical ventilation strategy. Compare two groups of the ventilator parameters, complications and hospital stay. Results There were statistical differences in PIP, PEEP and MAP between the two groups（P〈0.05）. There were statistical differences in the incidence of VALI and the length of stay between the two groups（P〈0.05）. Conclusion LPSV can reduce the incidence of VALI and shorten average hospital stay.