缝隙连接蛋白43在急性冠脉综合征预后评估中的临床意义

Prognosis Evaluation Clinical Significance of Connexin 43 in Acute Coronary Syndrome

目的探讨急性冠脉综合征(ACS)患者血清中缝隙连接蛋白43(Connexin 43,Cx 43)的水平,与冠脉狭窄程度及ACS危险分层之间的相关性。方法选取拟诊ACS患者88例,均行冠状动脉造影(CAG),根据CAG结果确诊ACS 70例作为研究组,18例冠脉无狭窄者为对照组。研究组又分为不同的亚组,采用酶联免疫吸附法(ELISA)测定血清CX 43浓度。结果 ACS组血清CX 43高于对照组(P<0.001);STEMI组CX 43水平高于NSTEMI组及UA组(P<0.05);三支病变组CX 43单支及双支病变组(P<0.05);高危组高于中危组和低危组(P<0.05)。Pearson相关分析,CX 43与病变程度及GRACE评分呈正相关。结论 ACS患者血浆CX 43增高,且与血管损伤程度及疾病的危险程度呈正相关。

Objective According to testing the concentration of connexin 43（CX 43） which is in serum of ACS to discuss the correlation among the connexin level,degree of coronary artery narrow and risk stratification.Methods Selected 88 patients with suspected ACS.All of them have the coronary angiography（CAG）.And according to the CAG results,there were 70 ACS cases,18 cases with coronary stenosis as the control group,by taking ELISA to assay concentration of serum Cx 43.Results Compared the concentration of CX 43 group of ACS was higher than NACS.The level of serum CX 43 of STEMI group is higher than NSTEMI and UA group（P〈0.05）.Comparison of GRACE score,the levels of serum CX 43,display the high-risk group and low-risk group respectively,medium risk group serum CX 43 level difference（P〈0.05）.There were differences between the three branch lesions group and single branch lesion,double vessel lesion（P〈0.05）.ACS group＇s Cx 43 has the positive correlation with pathological changes degree.and has the positive correlation with GRACE.Conclusion ACS patient＇s CX 43 rising up has the relationship with vascular injury situation.CX 43 level rising up shows the patches of ACS are unstable.