丹参和内固定对胫骨远端骨折愈合的影响研究

Study on the Effect of Salvia Miltiorrhiza and Internal Fixation on the Healing of Distal Tibial Fractures

目的探讨丹参结合不同内固定方案治疗胫骨远端骨折的效果,明确丹参对于骨折愈合的价值。方法回顾性分析承钢医院骨科226例胫骨远端骨折患者急诊内固定手术的治疗效果,根据丹参使用分为丹参组114例(丹参与加压板亚组、丹参与锁定加压钢板亚组以及丹参与髓内钉亚组)和内固定组112例(加压钢板固定亚组、锁定加压钢板固定亚组以及髓内固定亚组),在治疗后1周、2周、4周以及8周时对比各组间骨痂形成情况,同时对比分析术后住院时间和骨折愈合情况。结果术后2周以后在相同时间点,丹参组的骨痂计分优于内固定组,并且骨折愈合用时、术后住院时间低于内固定组,其中丹参与锁定加压钢板组的各项指标优于其他各组,P<0.05,差异具有统计学意义。结论丹参联合内固定能够改善骨折愈合,丹参联合锁定加压钢板内固定可以作为胫骨首选治疗方案,治疗效果显著、愈合快。

Objective To discuss the effect of different internal fixation treatment combined with Salvia miltiorrhiza for distal tibial fractures and defining the value of Salvia miltiorrhiza for fracture healing.Methods A retrospective analysis of therapeutic efficacy was made in Department of orthopedics of Chenggang Steel Hospital where there were 226 cases of emergency patients with internal fixation of distal tibial fractures according to the use of Salvia miltiorrhiza.They were divided into the Salvia miltiorrhiza group 114 cases（Salvia miltiorrhiza and pressure plate sub group,Salvia miltiorrhiza and LCP group,Salvia miltiorrhiza and intramedullary nail group） and the internal fixation group 112 cases（compression fixation group,locking compression plate and intramedullary fixation sub group）,in 1 week,2 weeks,4 weeks and 8 weeks after the treatment,comparison of callus formation,the postoperative hospitalization time and fracture healing made among groups.Results At the same time after 2 weeks,the callus score of Salvia miltiorrhiza group was significantly better than the internal fixation group,and fracture healing time,postoperative hospitalization time were significantly lower than those of the internal fixation group.The indicators of salvia miltiorrhiza and locking compression plate group were better than other groups,P〈0.05,so the difference was significant.Conclusion Salvia miltiorrhiza combined with internal fixation can significantly improve fracture healing,and Salvia miltiorrhiza combined with locking pressurized plate internal fixation can be the best choice of tibial fractures treatment.The treatment effect is remarkable and fast healing.