胺碘酮对老年急性心肌梗死合并心房颤动患者短期预后影响研究

Effect of amiodarone on short-term prognosis in elderly patients with AMI complicated with AF

目的探讨胺碘酮对老年急性心肌梗死(AMI)合并心房颤动(AF)患者短期预后的影响。方法选择我院2012年1月至2014年12月收治的87例老年AMI合并AF患者作为研究对象,按照随机数字表法分为观察组(45例)和对照组(42例),观察组给予胺碘酮治疗,对照组给予毛花苷丙治疗。比较2组患者AF控制率、窦性心律维持效果、心室率和血压变化情况以及不良反应发生率。结果治疗后6、12、24、48h,观察组AF控制率均显著高于对照组(均P<0.05);AF转复后1个月内,观察组窦性心律维持总有效率为84%,显著高于对照组的55%(P<0.05);2组患者治疗后心室率均明显降低(P<0.05),组间比较差异无统计学意义(P>0.05);观察组不良反应发生率为7%,显著低于对照组的26%(P<0.05)。结论胺碘酮显著提高了老年AMI合并AF患者AF控制率,明显改善了患者短期预后,且不良反应少,值得临床重视。

Objective To investigate the effect of amiodarone on short-term prognosis in elderly patients with AMI complicated with AF.Methods From January 2012 to December 2014,87 cases of elderly patients with AMI and AF were selected as the research object.The observation group received the treatment of amiodarone,and the control group was given Lanatoside C treatment.The AF control rate,sinus rhythm maintenance effect,ventricular rate and blood pressure changes and adverse reactions were compared between the two groups.Results At 6,12,24,48 hafter treatment,the control rate of the observation group was significantly higher than that of the control group（P〈0.05）;Within 1months after the cardioversion,the total effective rate in the observation group was 84%,significantly higher than 55%in the control group（P〈0.05）;The heart rate of the two groups were significantly decreased after treatment（P〈0.05）,and the difference was not statistically significant（P〈0.05）.The incidence of adverse reactions in observation group was 7%,which was significantly lower than 26%in control group（P〈0.05）.Conclusion Amiodarone significantly increased the AF control rate in elderly patients with AF and AMI,significantly improved the short-term prognosis of patients.It has less adverse reactions,and it is worthy of clinical attention.