糖尿病性黄斑水肿的心血管危险因素研究

Cardiovascular Risk Factors of Diabetic Macular Edema

目的探讨糖尿病性黄斑水肿心血管相关危险因素。方法回顾性纳入223例糖尿病性视网膜病变患者,其中糖尿病性黄斑水肿患者70例。记录患者一般信息、实验室检查及临床情况,运用Logistic回归分析糖尿病性黄斑水肿的相关心血管疾病危险因素。结果共纳入糖尿病性黄斑水肿患者70例。与无黄斑水肿患者相比较,DME患者女性较多见(P=0.007),糖尿病病程更长(P=0.001),收缩压更高(P=0.000),体重指数较大(P=0.001),低密度脂蛋白胆固醇(P=0.015)、空腹血糖(P=0.002)水平更高,而高密度脂蛋白胆固醇水平偏低(P=0.036)。二元Logistic回归分析显示糖尿病病程(P=0.000)、体重指数(P=0.003)、收缩压(P=0.001)、空腹血糖(P=0.037)、低密度脂蛋白胆固醇(P=0.008)等均与DME相关。结论糖尿病性黄斑水肿可能与糖尿病病程、血压、血脂、血糖以及体重指数相关。

Objective To study the cardiovascular risk factors of diabetic macular edema （DME）. Methods Totally 223 patients with diabetic retinopathy were retrospectively included. Routine information, clinical features, and labortary parameters were analyzed, and binary logistic regression was used to assess the cardiovascular risk factors of DME. Results Seventy patients with DME were included. Patients with DME bad more female, longer duration of diabetes, higher levels of systolic pressure, fasting blood - glucose, low density lipoprotein cholesterol, body mass index （BMI） , and lower high density lipoprotein cholesterol （P 〈 0.05 ）. Logistic regression model demonstrated that duration of diabetes, blood pressure, blood sugar, low density lipoprotein cholesterol, and BMI （P 〈 0.05） were all as- sociated with DME. Conclusion Duration of diabetes, blood pressure, blood sugar, low density lipoprotein cholesterol, and BMI are all associated with DME.