含离子交换基团的载药栓塞微球的制备及性能研究

Preparations and property of drug-loaded embolic microsphere containing ion exchange groups

将2-丙烯酰胺-2-甲基丙磺酸制备成预聚物,然后与海藻酸钠溶液共混,通过反相悬浮交联法制备成含离子交换基团（—COOH,—SO3H）的互穿网络聚合物载药栓塞微球,微球呈规整球形,粒径集中分布在300-700μm之间。该微球负载抗癌药物阿霉素,24h内载药率最高可达41%,较纯海藻酸钠微球提高74%,其原因是互穿网络结构中磺酸基团的引入,增加了离子交换载药方式,直接提高了载药率;同时互穿网络结构的形成,改善了微球内部结构,增加了微孔通道,有利于海藻酸中—COOH与阿霉素药物的离子交换和物理方式载药,几种因素的协同效应导致载药率的提高及载药速率加快。所得产物在介入法治疗肿瘤领域具有光明应用前景。

Interpenetrating polymer network drug-loaded embolic microspheres containing ion exchange groups（—COOH,—SO3H）were prepared by crosslinking reactions in an inverse suspension system,using the mixed solution of poly[2-acrylamide-2-methylpropane sulfonic acid]and sodium alginate as the raw materials.The microspheres showed regular spherical shape with a size distribution mainly ranging from 300μm to 700μm.The microspheres could load doxorubicin with a loading rate as high as 41.0%in 24 hours,raising 74% compared to that of pure alginate microspheres.The reason was that the introduction of the ion exchange groups improved the drug loading rate directly.Additionally,the internal structure of the microspheres was improved and more pore channels were created,which enhanced the ion exchange of COOH with doxorubicin and drug-loading in physical manner.The synergy of the factors led to the high loading rate and loading speed.The product had a bright prospect in the field of interventional treatment of tumor.