兴安毛连菜的黄酮成分研究

Flavonoids from Picris davurica

采用大孔吸附树脂、MCI树脂、Sephadex LH-20凝胶和反相硅胶ODS等柱色谱技术,从兴安毛连菜（Picrisdavurica Fish.）的抗炎活性部位分离得到11个黄酮化合物,根据化合物的理化性质和波谱数据,分别鉴定为isoestin-7-O-β-D-glucopyranosyl-2＇-O-α-L-arabinopyranoside（1）、isoetin-7-O-β-D-glucopyranosyl-2＇-O-β-D-xyloypyranoside（2）、isoetin-7-O-β-D-glucopyranosyl-2＇-O-α-D-glucopyranoside（3）、isoetin 5＇-O-β-D-glucopyranoside（4）、isoetin-2＇-O-β-D-xyloypyranoside（5）、isoetin-4＇-O-β-D-O-β-Dglucopyranoside（6）、isoetin-7-O-β-D-glucopyranoside（7）、isoestin-2＇-O-α-L-arabinopyranoside（8）、木犀草素-7-O-β-D-葡萄糖苷（9）、isoetin（10）和木犀草素（11）。所有化合物均为首次从该植物中分离得到,其中化合物1~8为首次从毛连菜属植物中分离得到。

Eleven compounds were purified from the anti-inflammatory extract of Picris davurica by column chromatograph on HP20 macroporous resin,MCI,sephadex LH-20 and ODS. Their structures were determined by the spectra data of NMR and MS as isoestin7-O-β-D-glucopyranosyl-2＇-O-α-L-arabinopyranoside（ 1）,isoetin-7-O-β-D-glucopyranosyl-2＇-O-β-D-xyloypyranoside（ 2）,isoetin-7-O-β-D-glucopyranosyl-2＇-O-α-D-glucopy-ranoside（ 3）,isoetin 5＇-O-β-D-glucopyranoside（ 4）,isoetin-2＇-O-β-D-xyloypyranoside（ 5）,isoetin-4＇-O-β-D-O-β-D-glucopyranoside（ 6）,isoetin-7-O-β-D-glucopyranoside（ 7）,isoestin-2＇-O-α-L-arabinopyranoside（ 8）,luteolin-7-O-β-D-glucopyranosie（ 9）,isoetin（ 10） and luteolin（ 11）. All compounds were isolated from this plantfor the first time. Among them,compounds 1-8 were isolated from the genus Picris for the first time.