丙酮醛抗肿瘤机制的研究进展

Advance on the Anti-tumor Mechanism of Methylglyoxal

丙酮醛作为正常的生理代谢产物,可来源于多条代谢通路,最主要的来源是糖酵解途径,丙酮醛分解主要是在乙二醛酶系统的作用下最终转化为D-乳酸。丙酮醛具有高度的活性和细胞毒性,它在多种类型的肿瘤组织中含量较低。丙酮醛能够抑制恶性肿瘤细胞的增殖、诱导其凋亡、抑制肿瘤的转移,并能通过增强机体的免疫力以及提高对现有抗肿瘤药物的敏感性等作用更进一步地发挥抗肿瘤效应。深入研究其抗肿瘤机制能够为临床试验提供依据、使其成为有潜力的新型抗肿瘤药,该文就丙酮醛可能的作用机制予以综述。

As a normal physiological metabolites, methylglyoxal（MG） is formed from various metabolic routes, among them glycolytic pathway provides the most important source. MG is mainly catalyzed by glyoxalasesystem, it converts to D-lactate finally. MG is highly reactive and it processes cell toxicity. MG is lower in many types of cancers. The anticancer effect of MG is due to its anti-proliferative properties, the abilities of inducing apoptosis and inhibiting tumor metastasis, it can also enhance immune system and increase sensitivity to antitumor agents. Further investigation of the mechanisms will provide evidences for next stage clinical research and make this compound to be a potential therapeutic agent, the aim of this review is to summarize the mechanisms of MG′s antitumor effect.