肿瘤微环境对乳腺癌发生发展的影响

The effects of tumor microenvironment on the development and progression of breast cancer

肿瘤微环境(TME)在局部耐药性、免疫逃脱和远端转移等多个肿瘤发生、发展的步骤中起关键作用。依据不同个体的TME,准确评估和选择临床用药,可有效控制原位癌和转移癌的恶性转化。目前,治疗癌症的主要方法是化疗,由于TME中良性细胞可调节癌细胞对标准化疗和靶向药物治疗的反应,因此,结合靶向TME治疗会取得更理想的临床疗效。本文就乳腺癌TME中细胞外基质(ECM)、肿瘤相关成纤维细胞、肿瘤相关巨噬细胞、调节性T细胞和骨髓间质干细胞对肿瘤发生、发展的作用机制进行综述。

Tumor microenvironment（TME） plays a key role in the development and progression of tumors, such as pro-moting local drug resistance, immune escape, and distal metastasis. According to the TME of different individuals, accurateevaluation and selection of clinical medication can effectively control the malignant transformation of carcinoma in situ andmetastatic cancer. At present, the main method to treat cancer is chemotherapy, TME can regulate the reaction of the tumorcells to the standard chemotherapy and target drug therapy, so the combination of the targeted TME therapy and chemothera-py will achieve better clinical efficacy. In this review, we summarized the mechanisms of TME in breast cancer, including ex-tracellular matrix, carcinoma-associated fibroblasts, carcinoma-associated macrophages, regulatory T cells and bone marrowmesenchymal stem cells, which providing a theoretical basis for the development of TME targeted therapy.