摘要
[目的]观察右归丸治疗肾阳虚型慢性肾脏病2-3期的临床疗效。[方法]选取80例肾阳虚型慢性肾脏病2-3期患者,随机分为治疗组和对照组,对照组(40例)予西医一体化治疗,治疗组(40例)在西医一体化治疗的基础上加用右归丸,观察两组患者在治疗前、治疗后的血清肌酐(Scr)、估算肾小球滤过率(e GFR)、24 h尿蛋白定量及中医证候积分的变化情况,观察周期为24周。[结果]在血清Scr、24 h尿蛋白定量、e GFR及中医证候改善方面,治疗组均优于对照组(P〈0.05)。[结论]右归丸可有效改善肾阳虚型慢性肾脏病2-3期患者的中医证候积分及其肾功能,降低24 h尿蛋白定量,具有一定的肾脏保护作用,并且临床运用安全。
[Objective] To observe clinical efficacy of Yougui pill on the patients with chronic kidney disease(CKD) stage 2-3 with kidney Yang deficiency type. [Methods] The 80 patients were randomly divided into therapyeutic group(40 cases) and Control group(40 cases). Patients in therapyeutic group were given orally Yougui pill combined with integrated therapy, while patients in control group just only given integrated therapy. Before and after the treatment, serum creatinine, estimated glomerular filtration rate, 24 h urine protein quantity and accumulate points of traditional Chinese medicine syndrome were measured. The observation period was 24 weeks.[Results] Serum creatinine, 24 h urine protein quantity in therapyeutic group were decreased significantly( P〈0.05), and estimated glomerular filtration rate in this group increased significantly(P〈0.05). [Conclusion] Yougui pill has a certain degree protection to early kidney injury.
出处
《天津中医药》
CAS
2016年第4期217-219,共3页
Tianjin Journal of Traditional Chinese Medicine
基金
上海市医学重点专科资助项目(ZK2012A34)
关键词
慢性肾脏病
肾阳虚证
右归丸
临床疗效
chronic kidney disease
kidney Yang deficiency syndrome
Yougui pill
clinical curative effect