肿节风抗肿瘤作用及其机制的研究进展

The Progress in the Antitumor Effect and Mechanism of Zhongjiefeng(Sarcandra Glabra)

就肿节风抗肿瘤作用实验研究、临床研究及其相关机制的研究情况作一综述。体内外研究表明肿节风对消化道肿瘤、呼吸道肿瘤、乳腺癌等均有较强的细胞毒作用,配合化疗药物应用可发挥增效减毒的双向作用。其抗肿瘤机制主要与抑制细胞增殖、诱导细胞凋亡及免疫调节等有关。肿节风是具有潜在抗肿瘤效应的有效药物,但由于肿节风化学成分复杂,其有效成分或有效部位及相关的分子作用机制尚未完全明确,有待于进一步深入研究。

The research progress of antitumor effect and related mechanisms, experimental research and clinical research were reviewed in this paper. In vitro and in vivo studys, Zhongjiefeng（sarcandrae herba） was proved to be cytotoxic agent against tumor cells, including digestive tract tumor, respiratory tumors and breast cancer. Besides, it showed synergism and attenuation actions with antitumor agents. The antitumor mechanism of Zhongjiefeng（sarcandrae herba） is involved with many aspects, such as inducing cell apoptosis and immunomod- ulatory. As Zhongjiefeng（sarcandrae herba） is single herb extracts with complex chemical composition, further studies need to be carried out on the effective chemical constituents and the relationship between the structure and antitumor activity.