期刊文献+

M1型巨噬细胞的葡萄糖分解代谢 被引量:5

下载PDF
导出
摘要 巨噬细胞在机体先天性免疫中发挥着重要作用。巨噬细胞在γ干扰素(IFN-γ)或脂多糖(LPS)刺激下,极化为M1型巨噬细胞,其主要的糖代谢途径随之改变,主要表现为糖酵解取代三羧酸循环成为产生ATP的主要途径,并且糖酵解过程的中间产物还可作为M1型巨噬细胞产生促炎细胞因子的原料参与炎症反应。本文将重点讨论M1巨噬细胞的葡萄糖分解代谢。
出处 《生理科学进展》 CAS CSCD 北大核心 2016年第2期149-152,共4页 Progress in Physiological Sciences
基金 河南省重点学科经费资助课题
  • 相关文献

参考文献1

二级参考文献111

  • 1Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immuno12002; 20:197-216.
  • 2Chen GY, Nunez G. Sterile inflammation: sensing and react- ing to damage. Nat Rev lmmuno12010; 10:826-837.
  • 3Warburg O, Wind F, Negelein E. The metabolism of tumors in the body. JGen Physiol 1927; 8:519-530.
  • 4Sbarra AJ, Karnovsky ML. The biochemical basis of phago- cytosis. I. Metabolic changes during the ingestion of parti- cles by polymorphonuclear leukocytes. J Biol Chem 1959; 234:1355-1362.
  • 5Guthrie LA, McPhail LC, Henson PM, Johnston Jr RB. Prim- ing of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased ac- tivity of the superoxide-producing enzyme. J Exp Med 1984; 160:1656-1671.
  • 6Borregaard N, Herlin T. Energy metabolism of human neutro- phils during phagocytosis. J Clin Invest 1982; 70:550-557.
  • 7Hard GC. Some biochemical aspects of the immune macro- phage. BrJExp Pathol 1970; 51:97-105.
  • 8Newsholme P, Gordon S, Newsholme EA. Rates of utiliza- tion and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages. Biochem J 1987; 242:631-636.
  • 9Newsholme P, Curi R, Gordon S, Newsholme EA. Metabo- lism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages. Biochem J 1986; 239:121- 125.
  • 10Krawczyk CM, Holowka T, Sun J, et al. Toll-like receptor-in- duced changes in glycolytic metabolism regulate dendritic cell activation. Blood 2010; 115:4742-4749.

共引文献85

同被引文献27

引证文献5

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部