心境障碍和甲状腺功能异常相关的研究进展

Research Progress of Mood Disorder and Relevant Thyroid Gland Dysfunction

心境障碍是常见的精神障碍疾患,主要表现为心境和情感的改变,通常表现为持久的情感高涨或低落,其高致残率对社会造成了极为严重的危害。甲状腺激素异常见于心境障碍患者,并且甲状腺功能异常加大了人群心境障碍的患病率。心境障碍患者甲状腺功能障碍主要表现为甲状腺激素水平的异常,甲状腺素(T4)向三碘甲状腺原氨酸(T3)转化异常,下丘脑-垂体-甲状腺(HTP)轴功能的亢进或抑制。甲状腺激素对于心境障碍患神经递质有所影响,异常的甲状腺激素水平对基因的调节和生化改变相关联。甲状腺抗体同样是心境障碍发病的关联因素。本文总结了心境障碍和甲状腺功能异常相关的研究进展,为进一步研究心境障碍和甲状腺功能异常提供一定的依据。

Mood disorder is a common mental disorder with the changes of mood and emotion as the major performances and lasting high or low emotion as usual manifestations. The high disability rate of mood disorder causes serious harm to society.Thyroid hormone abnormalities is common in patients with mood disorders and abnormal thyroid function increases the prevalence of mood disorders. Thyroid dysfunction of patients with mood disorders manifests mainly as thyroid hormone abnormalities,the abnormal conversion from T4 to T3and HTP axis function hyperfunction or inhibition. Thyroid hormone influences neurotransmitter of mood disorders and abnormal thyroid hormone level influences gene expression. Thyroid antibodies are connected factors of the mood disorders onset. Research progress of mood disorder and relevant thyroid gland dysfunction was summarized in this article,which provides a certain basis for the further study of mood disorder and abnormal thyroid function.