社区2型糖尿病患者影响糖化血红蛋白达标率因素分析

The influencing factors analysis of glycosylated hemoglobin among type 2 diabetic community patients

目的调查社区2型糖尿病患者糖化血红蛋白达标情况,探讨影响糖化血红蛋白达标的相关因素,为进一步改善2型糖尿病的控制效果、制定合理治疗方案提供理论依据。方法对716例2型糖尿病患者进行糖化血红蛋白检测、实验室常规生化项目检查,包含空腹血糖、餐后2h血糖、甘油三酯、总胆固醇、尿素氮、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、尿肌酐、尿酸、尿微量白蛋白等,同时收集患者一般资料、治疗方案信息,依据糖化血红蛋白<7%达标标准,按性别、年龄、病程、治疗方案等分组讨论影响因素。结果 716例2型糖尿病患者的糖化血红蛋白达标率是42.1%;糖化血红蛋白与糖尿病患者病程、治疗方案相关,具有统计学意义(P<0.05);糖化血红蛋白达标率与空腹血糖、餐后2h血糖以及尿微量白蛋白正常与否密切相关。结论合理控制糖化血红蛋白值,可有效控制糖尿病及并发症的发生和发展。

Objective To investigate the current blood glucose compliance status of type 2diabetic community patients,analyze the influencing factors of glycosylated hemoglobin（HbA1c）and therefore provide theoretical basis and references for improving the control of diabetes and developing reasonable treatment plans.MethodsWe measured and collected the HbA1 clevel and clinical routine biochemistry test results of 716 type 2diabetic community patients,including their fasting blood-glucose（FPG）,2hour postprandial blood glucose（2hPG）,triglycerides（TG）,total cholesterol（TC）,urea nitrogen（BUN）,high-density lipoprotein cholesterol（HDL）,low density lipoprotein cholesterol（LDL）,urine creatinine（Ucr）,uric acid（UA）and urine microalbumin（UMA）.We also collected the demographic information,prior treatment information of them.We analyzed the data using HbA1c〈7% as the standard of blood glucose control.Results The compliance rate of HbA1 cfor the community patients was 42.1%.HbA1 clevel was significantly different according to the course of disease and treatments（P 〈0.05）.The compliance rate of HbA1 cwas related to whether FPG,2h-PBG and UMA were normal.Conclusion The appropriate management of HbA1 ccould effectively control the development of diabetes and complication.