不稳定型心绞痛患者hsCRP与血栓前状态分子标志物水平变化及其相关性

Level Changes and Correlation Analysis of hsCRP and Pre - thrombosis State Molecular Markers in Patients with Unstable Angina Pectoris

目的观察不稳定型心绞痛（UAP）患者体内高敏C-反应蛋白（hsCRP）与血栓形成前状态（PTS）分子标志物水平变化及其相关性，并探讨其临床意义。方法选择UAP的患者59例（UAP组）、冠状动脉粥样硬化患者42例（冠脉硬化组）、以及正常对照者43例（对照组），分别测定其体内hsCRP、PTS分子标志物水平，并采用直线相关分析法分析参数之间的相关性。结果UAP组患者体内的hsCRP、血管性假性血友病因子（vWF）、D-二聚体、纤维蛋白原（FIB）、血栓前体蛋白（TpP）水平均明显高于冠脉硬化组（P〈0．05），冠脉硬化组患者体内的hsCRP、vwF、D-二聚体、FIB、TpP水平也均明显高于对照组（P〈0．05）。相关性分析显示UAP患者体内的hsCRP水平与vWF、D-二聚体、FIB、TpP水平均呈明显正相关（P〈0．05）。结论UAP患者体内存在明显的hsCRP、血栓前状态分子标志物水平变化，并且两者变化的程度密切相关，这种相关性可能在UAP病理过程中起到重要作用，测定这两项指标对于判定UAP患者病情及严重程度都有一定的临床意义。

Objective To observe changes and correlation of hsCRP and prethrombosis state （PTS）molecular markers in patients with unstable angina pectoris（UAP） ,and to explore their clinical significance. Methods 59 patients with UAP（ UAP group） ,42 patients with coronary artery atherosclerosis （coronary sclerosis group）, as well as 43 normal people （control group）were selected. Levels of hsCRP and PTS molecular markers were measured, and the cor- relation between these parameters was analyzed by linear correlation analysis. Results Levels of hsCRP, vWF, D - dimer,fibrinogen（FIB） and thrombus precursor protein（TpP） in UAP group were significantly higher than those in cor- onary sclerosis group （ P 〈 0.05 ）. Levels of hsCRP, vWF, D - dimer, FIB and TpP in coronary sclerosis group were ob- viously higher than those in control group（P 〈 0.05 ）. Correlation analysis showed that levels of hsCRP, vWF, D- di- met, FIB and TpP in patients with UAP were positively correlated（P 〈 0.05 ）. Conclusion There are obvious chan- ges in levels of hsCRP and PTS molecular markers in patients with UAP, and the degree of changes is closely related. This correlation may play an important role in pathological process of UAP. There is a certain clinical significance to determine the severity in patients with UAP by detecting these two indexes.