市售雄黄药材及饮片质量考察

Quality Investigation of Realgar in Commercially Available Medicinal Materials and Decoction Pieces

目的：进行了市售雄黄药材及饮片的晶形结构及主成分硫化砷含量的测定,考察了市售雄黄药材及饮片的质量。方法：采用X射线衍射法对市售雄黄药材及饮片进行了物相（晶形）分析,采用《中国药典》（2010年版一部）雄黄项下滴定法测定了雄黄药材及饮片中硫化砷含量。结果：12号、13号雄黄药材主成分是α雄黄（As S）和β雄黄（As4S4）混合体,14号、15号雄黄药材主成分是α雄黄（As S）,16号雄黄药材主成分是β雄黄（As4S4）,6号雄黄饮片为二氧化硅和α雄黄（As S）的混合体。市售药材中硫化砷含量均在92%~99%范围内,含量均大于90%;雄黄饮片中硫化砷含量均在7%~87%范围内,含量均小于90%。结论：X射线衍射法可以对雄黄进行定性鉴别,市售雄黄饮片整体的质量存在参差不齐的现状。

Objective： The crystal construction and the content of principal component（ As S） were determined in order to investigate the quality of realgar in commercially available medicinal materials and decoction pieces. Methods： Crystal construction of realgar was tested by X-ray diffraction,As S content was determined by titration based on the analysis method of realgar recorded in Chinese Pharmacopoeia（ 2010edition）. Results： The experiments indicated that the twelve and thirteen samples were the mixture of α-realgar（ As S） and β-realgar（ As4S4）; the fourteen and fifteen samples mainly included α-realgar（ As S）; the sixteen sample contained β-Realgar（ As4S4）; the six sample was the mixture of silicon dioxide and α-realgar（ As S）. The contents of realgar ranged from 92% to 99% in the commercially available medicinal materials,and all of them were more than 90%; while the contents of realgar in the decoction pieces were from the range of 7% to 87%,and all of them were less than 90%. Conclusion： X-ray diffraction can be used to identify realgar,and the overall quality of realgar are uneven in commercially available decoction pieces.