髓样细胞触发受体-1在寻常型银屑病中的表达及意义

Expression of Trem-1 and its significance in psoriasis vulgaris

目的通过对比髓样细胞触发受体-1(Trem-1)在寻常型银屑病患者与正常人皮肤组织及血液中的表达差异,探索寻常型银屑病发病的可能机制。方法采用免疫组化及实时荧光定量PCR的方法检测Trem-1在不同组织中的表达情况,应用SPSS21.0统计软件进行统计学分析。结果 Trem-1在寻常型银屑病患者皮损中表达增加,主要表达于表皮全层,正常皮肤组织中主要表达于基底细胞层,其表达差异具有统计学意义(P<0.05)。Trem-1mRNA在寻常型银屑病皮损、血液中表达升高,与正常组相比差异具有统计学意义(P<0.05);且Trem-1mRNA表达与银屑病皮损面积和严重程度指数(PASI)呈正相关(P<0.05)。结论Trem-1的异常表达可能参与了寻常型银屑病发病,Trem-1可能成为治疗寻常型银屑病的潜在靶点。

Objective To study the expression of triggering receptor expressed on myeloid cells-1 （Trem-1） in psoriatic vulgaris and normal skin tissues and blood, and to explore the potential pathogenesis of psoriasis. Methods Immunohistochemistry and Real-time PCR were used to detect the expression of Trem-1 in the blood and tissues of normal skin and psoriasis. Results The positive expression rate of Trem-1 in psoriatic lesion was significantly higher than normal tissue. Trem-1 was expressed in the whole epidermis, with a significant difference （P〈0.05）. The mRNA expression of Trem-1 was significantly higher in psoriatic skin tissues and blood than in normal skin tissues and blood （P〈0. 05）. Moreover, the mRNA expression of Trem-1 was positively correlated with PASI （P〈 0.05）. Oonclusion Abnormal expression of Trem-1 might be related to the pathogenesis of psoriasis. Trem-1 will cure psoriasis vulgaris as the potential therapeutic target.