功能性消化不良患者躯体化与焦虑相关性的研究

Research on the relation between somatisation and anxiety in patients with functional dyspepsia

目的:探讨功能性消化不良(functional dyspepsia,FD)患者躯体化与焦虑的相关性。方法:共194例门诊部就诊的FD患者完成患者健康问卷躯体症状群量表(patient health quesitonnaire-15,PHQ-15)及焦虑量表(self-rating anxiety scale,SAS),统计并分析焦虑与躯体化症状的分布、二者关系及主要躯体化症状对焦虑的影响。结果:FD患者焦虑状态发生率为39.7%;焦虑评分(46.8±12.8)分;总的PHQ-15评分为(6.2±3.5)分;相关分析显示FD(r=0.611,P=0.000)、上腹痛综合征(epigastric pain syndrome,EPS)(r=0.412,P=0.011)、餐后不适综合征(postprandial distress syndrome,PDS)(r=0.678,P=0.000)、重叠组(r=0.838,P=0.000)躯体化与焦虑皆呈正相关;线性回归分析发现四肢或关节痛(β=5.576,P=0.000)、头痛(β=6.747,P=0.000)、感到疲乏或精力不足(β=2.821,P=0.005)、心悸(β=6.954,P=0.000)是影响焦虑状态更明显的因素(P<0.05)。结论:FD患者躯体化症状及焦虑状态常见,且二者关系明显,这些研究结果对进一步研究及提高FD的疗效可能是有益的。

Objective： To explore the relationship between somatic symptoms and anxiety in patients with functional dyspepsia（ FD）. Methods： One hundred and ninety-four consecutive outpatients with FD were enrolled to finish the Patient Health Questionnaire-15（ PHQ-15） and Zung’s Self-Rating Anxiety Scale（ SAS）,and analyze the distribution of anxiety and somatic symptoms and their relationship,and the effects of somatic symptoms on anxiety. Results： The incidence of anxiety in all selected FD patients was 39. 7%.The scores of anxiety and PHQ-15 were（ 46. 8 ± 12. 8）,（ 6. 2 ± 3. 5） respectively. Somatisation in FD（ r = 0. 405,P = 0. 000）,EPS（ r = 0. 292,P = 0. 025）,PDS（ r = 0. 494,P = 0. 001） and overlap group（ r = 0. 569,P = 0. 000） were positively correlated with anxiety. Pain in your arms,legs,or joints（ β = 5. 576,P = 0. 000）,headaches（ β = 6. 747,P = 0. 000）,feeling tired（ β = 2. 821,P =0. 005）,heartbeats（ β = 6. 954,P = 0. 000） were distinctly associated with anxiety by Multiple linear regression analysis（ P 〈 0. 05）.Conclusion： Somatic symptoms and anxiety are common and have a significant relationship in FD patients. These results may be helpful in further studies and improvement on the treatment of FD.