大型血小板比率与2型糖尿病并发缺血性脑卒中的关系

Relationship between large platelet ratio and type 2 diabetes mellitus complicated by ischemic stroke

目的:探讨大型血小板比率(platelet-large cell rate,P-LCR)与2型糖尿病(type 2 diabetes mellitus,T2DM)并发缺血性脑卒中的关系。方法:选取66例T2DM并发缺血性脑卒中患者作为试验组,67例单纯T2DM患者作为对照组。比较两组一般资料及外周血中血小板4项参数,通过多因素Logistic回归分析评价影响T2DM并发缺血性脑卒中的独立危险因素。结果:两组患者年龄、收缩压、空腹血糖、糖化血红蛋白、血小板平均体积(mean platelet volume,MPV)、血小板分布宽度(platelet distribution width,PDW)及P-LCR比较差异均有统计学意义(P<0.05或P<0.01);而血小板计数(platelet count,PLT)比较差异无统计学意义(P>0.05)。P-LCR与MPV、PDW明显正相关(r=0.67,P<0.05;r=0.63,P<0.05);多因素Logistic回归分析显示,年龄、P-LCR、收缩压及糖化血红蛋白是T2DM并发缺血性脑卒中的独立危险因素。结论:T2DM并发缺血性脑卒中患者P-LCR显著增加,可作为评估T2DM发生缺血性脑卒中的独立危险因素。

Objective： To investigate the relationship between platelet-large cell rate（ P-LCR） and type 2 diabetes mellitus（ T2DM） complicated by ischemic stroke. Methods： A total of 66 patients with T2 DM complicated by ischemic stroke were selected as trial group,and 67 patients with T2 DM alone as control group. The general data and peripheral blood platelet 4 parameters of two groups were compared,and the independent risk factors of T2 DM patients complicated by ischemic stroke were evaluated by multivariate Logistic regression analysis. Results： There was statistical significance between two groups by comparison to the age,systolic blood pressure,fasting blood glucose,glycosylated hemoglobin,mean platelet volume（ MPV）,platelet distribution width（ PDW） and P-LCR（ P 〈 0. 05 or P 〈 0. 01）,but significant difference was not shown regarding the platelet count（ PLT）（ P 〉 0. 05）. The P-LCR was positively correlated with MPV and PDW（ r = 0. 67,P 〈 0. 05; r = 0. 63,P 〈 0. 05）. The result of multivariate Logistic regression analysis showed that the age,P-LCR,systolic blood pressure and glycated hemoglobin were the independent risk factors of T2 DM patients complicated by ischemic stroke. Conclusion： The P-LCR increases significantly in T2 DM patients complicated by ischemic stroke,so it can be used as an independent risk factor in the diagnosis of T2 DM patients complicated with ischemic stroke.