精准医疗快速发展时期结直肠癌治疗沉淀与突破

The reflection and breakthrough of colorectal cancer treatment in the rapid developing era of precision medicine

目前,结直肠癌的多学科综合治疗理念被越来越多的人接受。同时,分子分型指导下的个体化治疗也日趋成熟。结直肠癌是高度异质性肿瘤,其发病由一系列遗传事件和表观遗传学事件所造成。随着大数据以及精准医疗时代的到来,结直肠癌分子分型,包括左、右半结肠以及分子生物标志物的分型越来越重要。如何识别结直肠癌的异质性和个体间差异、如何更好地进行精准治疗,将成为未来结直肠癌治疗的焦点。

The multidisciplinary approach to colorectal cancer has been well accepted,recently. Meanwhile,individualized drug therapy has been developed by the guidance of molecular subtyping. Colorectal cancer is a heterogeneous disease that develops as a consequence of both genetic and epigenetic events. In the new era of big data and precision medicine,the molecular subtype of colorectal cancer is becoming more and more important,including differentiation of molecular biomarkers and locations of cancer. The future direction of colorectal cancer treatment should focus on dissecting tumor heterogeneity,distinguishing individual biological behavior,and practicing precision medicine.