维医异常黏液质型阳痿患者临床病理参数和性激素水平变化及相关性研究

The study of sex hormones and clinicopathologic parameters changes and their correlations in male impotence disease patients with abnormal phlegmatic syndrome

目的探讨维医异常黏液质型阳痿患者临床病理参数和性激素水平变化及二者相关性。方法临床上选取IIEF-5评分<22的阳痿患者112例,健康对照者28例,经维医分型分成正常对照组、异常黏液质型阳痿组和非异常黏液质型阳痿组,并采集其年龄、身高、体质量、体质指数(BMI)、腰围、血压、脉搏以及MSF-4评分,并检测性激素水平。结果 (1)性激素结果:异常黏液质型阳痿组与非异常黏液质型阳痿组T水平均显著低于正常对照组(P<0.05)。异常黏液质型阳痿组雌二醇(E2)、催乳素(PRL)、黄体生成素(LH)、促卵泡成熟激素(FSH)水平均显著高于正常对照组(P<0.05)。非异常黏液质型阳痿组E2、PRL、LH、FSH水平均显著高于正常对照组(P<0.05)。(2)临床病理参数结果:异常黏液质型阳痿组与非异常黏液质型阳痿组IIEF-5和MSF-4评分均显著低于正常对照组(P<0.05)。异常黏液质型阳痿组BMI、腰围及血压均显著高于正常对照组(P<0.05)。非异常黏液质型阳痿组血压及脉搏均显著高于正常对照组(P<0.05)。异常黏液质型阳痿组体质量、腰围及BMI均显著高于非异常黏液质型阳痿组(P<0.05);脉搏显著低于非异常黏液质型阳痿组(P<0.05)。(3)二者相关性分析:睾酮(T)与BMI、E2与IIEF-5及MSF-4、LH与IIEF-5及MSF-4、FSH与IIEF-5及MSF-4均呈显著负相关(P<0.05)。E2与血压呈显著正相关(P<0.05)。结论血清性激素含量的不同水平以及患者临床病理参数的改变可能是异常黏液质体液在阳痿患者体内的外在表现,血清性激素水平变化结合患者临床病理参数的改变可作为异常黏液质型阳痿的现代科学指标。

Objective To investigate the changes and correlations between male sex hormone levels and Clinicopathologic parameters of male impotence disease patients with abnormal phlegmatic syndrome.Methods A total of 112 male impotence disease patients whose IIEF-5score is below 22 and 28healthy males were collected and divided into normal group,impotence group with abnormal phlegmatic syndrome and impotence group without abnormal phlegmatic syndrome.The age,height,weight,BMI,waist circumference,blood pressure,pulse rate,MSF-4score were recorded and male sex hormone levels were detected.Results（1）Changes in sex hormone levels：Compared to normal group,serum testosterone（T）level is significantly lower and serum estradiol（E2）,prolactin（PRL）,luteinizing hormone（LH）,follicle-stimulating hormone（FSH）levels are significantly higher in impotence group with abnormal phlegmatic syndrome（P〈0.05）;Serum T level is significantly lower and E2,PRL,LH,FSH levels significantly higher in impotence group without abnormal phlegmatic syndrome（P〈0.05）;（2）Changes in clinicopathologic parameters：Compared to normal group,IIEF-5and MSF-4scores are significantly lower both in impotence group with abnormal phlegmatic syndrome and impotence group without abnormal phlegmatic syndrome（P〈0.05）;Body mass index（BMI）,waist circumference and blood pressure are significantly higher in impotence group with abnormal phlegmatic syndrome（P〈0.05）;Blood pressure and pulse rate are significantly higher in impotence group without abnormal phlegmatic syndrome（P〈0.05）.Compared to impotence group without abnormal phlegmatic syndrome,body weight,BMI,waist circumference are significantly higher and pulse rate significantly lower in impotence group with abnormal phlegmatic syndrome（P〈0.05）;（3）Correlations between sex hormone levels and clinicopathologic parameters：Serum T level positively correlates to BMI（P〈0.05）.Serum E2 level positively correlates to blood pressure and negatively correlates to IIEF-5and MSF-4scores（P〈0.05）.Serum LH and FSH levels both negatively correlates to IIEF-5and MSF-4scores（P〈0.05）.Conclusion The specific changes of sex hormone levels and Clinicopathologic parameters may be an external result of abnormal phlegmatic humor.Temperament differentiation in Uyghur medicine correlates with the sex hormone levels and clinicopathological parameters of impotence disease.Sex hormone levels and clinicopathological parameters may be helpful for the temperament differentiation of impotence disease patients in Uyghur medicine.