维药老鼠瓜凝胶剂制备工艺的优化

Preparation process optimization of Uygur medicine Capparis spinosa Gels

目的优化维药老鼠瓜凝胶刘的制备工艺。方法在单因素试验基础上,以卡波姆(X1,%)、甘油(X2,%)及无水乙醇(X3,%)的加入量为自变量,以粘度、触变性和屈服值的综合评分为因变量,采用星点设计法优选老鼠瓜凝胶剂的制备工艺,对试验结果数据进行二项式方程的拟合,根据最佳数学模型描绘效应面,确定最佳处方制备工艺并进行预测分析和处方验证。结果根据响应面图及等高线图可以确定其大致范围,并结合实际实验最终确定优选的最佳处方制备工艺为:卡波姆用量为1.5%,甘油用量为10.0%,无水乙醇用量为17.5%,且按最优处方进行的验证试验中OD的实测值为65.49,预测值为62.91,偏差率为4.10%,该模型真实值与预测值非常接近无太大差异,具有良好的预测性。结论根据星点设计实现了维药老鼠瓜凝胶处方制备工艺的优化,建立的拟合模型具有良好的预测性。

Objective To optimize the preparation process of Uygur medicine Capparis spinosagels.Methods On the basis of single factor tests,with viscosity,thixotropy and yield value of overall rating as dependent variable,central composite design was adopted to optimize this gel preparation technology by the amount of carbomeer（X1,%）,glycerin（X_2,%）and anhydrous ethonal（X_3,%）as independent variables,fitting of various mathematical equations were performed using a statistical software of Design-Expert.Preparation parameters were optimized through response surface plotted by optimum fitting equations,optimized procedure was validated through experimental preparation of Uygur medicine Capparis spinosa gels.Results According to the fitting model,find the quantitative relationships between three factors and three evaluation indexes;Optimal formulation was carbomeer 1.5%,glycerin 10.0%,anhydrous ethonal17.5%,Press optimization prescription conducted in verification experiment,test of the selecte optimal formulation indicated that there existed approximation between the observed and estimated value.Conclusion According to the central composite design-response surface methodology,preparation process of Uygur medicine Capparis spinosagels was optimized,the the established model can have good predictability.