宫颈上皮内瘤变LEEP治疗后转归相关因素分析

The Influence Factors of Relapse After the LEEP Surgery with CIN Patients

目的探讨宫颈上皮肉瘤变LEEP治疗后转归相关影响因素。方法随访回顾追踪179例经LEEP术后的宫颈上皮肉瘤变患者的临床资料,分析影响转归的相关因素。结果随访患者复发为13例,复发率为7.3%,未复发者和复发患者在年龄、是否经产妇、术前HPV感染、术前病理结果、病变范围(包括有无累及腺体)、手术切缘阳性情况等方面的差异具有统计学意义(P<0.05)。初次性生活年龄与吸烟与否不具有统计学差异。结论研究结果表明,年龄较高、经产妇、术前HPV阳性,CINⅢ级、病变累及超过2个或以上象限、病变累及腺体以及手术切缘阳性均为CIN患者经LEEP手术治疗后的高危因素。

Objective To evaluate the influence factors of relapse after the LEEP surgery with CIN patients. Methods In order to discuss the influence factors of relapse after the LEEP surgery,clinical data of 179 patients with CIN were reviewed. Results 13 patients were relapsed during the follow- up with the recurrence rate of 7. 3%. There was statistically significant difference in age,fertility status,preoperative HPV infection,preoperative CIN pathological results,surgical margin status,lesion involving glands or not,and extent of disease（ P 〈 0. 05）. But there was no significant difference in age of first sexual and smoking status. Conclusion Age,fertility status,preoperative HPV infection,preoperative CIN pathological results,surgical margin status,lesion involving glands or not,and extent of disease were the danger factors after the LEEP surgery with CIN patients.