乌司他丁治疗热射病的疗效分析

The clinical efficacy of ulinastatin for the treatment of patients with heatstroke

目的探讨乌司他丁治疗热射病的临床效果。方法选取2010年6月~2014年9月重症医学科（ICU）收治的热射病患者49例,随机分为常规治疗组（23例）和乌司他丁治疗组（26例）,常规治疗组给予物理降温、药物降温、脱水、镇静、脑组织保护剂、抗休克、维持水电解质平衡等治疗;乌司他丁治疗组在常规治疗组基础上,应用10万单位乌司他丁溶于500 m L氯化钠注射液中静脉滴注治疗,每天3次。观察两组治疗后的疗效。结果与常规治疗组相比,乌司他丁治疗组的体温下降时间明显缩短,住ICU时间明显缩短,对PT、Scr、BUN、ALT、CK等反应凝血功能及心、肝、肾功能指标改善更为明显,而且病死率降低。结论应用乌司他丁治疗热射病可以保护脏器功能,缩短患者病程,降低病死率,对热射病的治疗具有重要的意义。

Objective To explore the clinical effcicacy of ulinastain for the treatment of patients with heatstroke. Methods From June 2010 to September 2014, 49 cases of heatsroke patients treated in ICU of our hospital, were randomly divided into ulinastain treatment group and conventional treatment group. In conventional treatment group, the patients were given the treatment such as body temperature cooling, medicine temperature cooling, dehydration, sedation,brain tissue protection and electrolyte balance maintenance. In ulinastain treatment group, except for conventional treatment, were treated with ulinastain（100000 units into 500 ml saline, intravenously drip off 1 ~ 2 h, 3 rd/d） treatment. Results Compared with the conventional treatment group, the time of temperature drop and the time in ICU of the patients in ulinastain treatment group were shortened obviously, and their prothrombin time（PT）, creatinine（Scr）,urea nitrogen（BUN）, alanine transarninase（ALT） and creatine kinase（CK） were improved significantly. The fatality rate in ulinastain treatment group decreased obviously than conventional treatment group. Conclusion In patients with heatstroke, using ulinastain can improve the function of liver、kidney and heart, shorten the course of disease, and decrease the fatality rate, were better effect than conventional treatment.