姜黄素对STZ诱导C57BL/6小鼠血糖、血脂影响

Effects of Blood Glucose and Blood Lipid of Curcumin on C57BL/6 Mice Induced by STZ

目的:研究姜黄素对链脲佐菌素(STZ)诱导C57BL/6小鼠血糖以及血脂的影响。方法:链脲佐菌素(STZ)合并高脂肪饮食诱导糖尿病小鼠模型,并随机分为正常组、模型组、阳性药组和姜黄素组,正常组、模型组灌胃0.5%CMC-Na,阳性组灌胃二甲双胍0.3 g/kg,姜黄素组灌胃姜黄素0.2 g/kg,连续给药8周。第8周最后一次给药后测定血糖、血脂、糖耐量、胰岛素耐量水平。结果:灌胃葡萄糖出现糖负荷以后,二甲双胍组血糖水平明显低于模型组(P<0.05);糖负荷后1 h时,姜黄素组血糖值明显较低(P<0.05)。注射胰岛素1 h后,姜黄素组血糖值明显低于模型组(P<0.05);二甲双胍组1 h后血糖明显低于模型组(P<0.05)。模型组血糖和糖化血红蛋白水平显著高于正常对照组,差异均具有显著性(P<0.05)。姜黄素组血清TG、LDL-C、HDL-C与模型组相比明显下降,均有显著差异(P<0.05),而TC水平降低不明显。结论:姜黄素可降低STZ所致糖尿病小鼠的血糖,增加糖耐量,提高小鼠机体胰岛素的敏感性,同时可纠正糖尿病小鼠脂代谢紊乱。

Objective：To study the effects of blood glucose and blood lipid of curcumin on C57BL/6 mice induced by STZ. Methods：we used the high fat and streptozotocin（STZ）to induce the diabetic mice model,and were randomly divided into normal group,model group,positive drug group and curcumin group,gavage for 8 weeks. Then to test the blood glucose,glucose tolerance,insulin tolerance and lipid. Results：After the glucose load,the blood sugar values of metformin group was significantly lower than that in the model group（P〈0.05）;1h after glucose load,curcumin group blood sugar values were significantly lower（P〈0.05）. After injection insulin 1 h,the blood sugar value of curcumin group was obviously lower than that of model group（P〈0.05）;metformin group were significantly lower than the model group（P〈0.05）. The blood glucose and glycated hemoglobin levels of model group were significantly higher than those in normal control group（P〈0.05）. The serum TG,LDL-C,HDL-C of curcumin group decreased obviously compared with the model group,there was significant difference（P〈0.05）,while the TC level did not significantly decrease. Conclusion：The curcumin can reduce blood glucose of diabetic mice which were induced by STZ,increase the glucose tolerance and the insulin sensitivity,also can correct the disorder of lipid metabolism in diabetic rats.