参附注射液对急性失代偿心力衰竭患者美托洛尔美托洛尔耐受性的影响

The influence of Shen- fu injection on doses of Metoprolol in patients with acute decompensated chronic heart failure

目的研究参附注射液对慢性心力衰竭患者美托洛尔耐受性的影响。方法以失代偿期慢性心力衰竭的住院患者为研究对象,随机分为参附注射液组30例和对照组32例,通过分析美托洛尔使用剂量、心率、平均动脉血压、血肌酐、血尿素氮等变量,判断参附注射液对美托洛尔使用剂量的影响。结果参附注射液组美托洛尔使用剂量明显高于对照组,差异有统计学意义(P<0.05),而对心率、平均动脉血压、血肌酐、血尿素氮等变量无显著影响,差异无统计学意义(P>0.05)。结论对于失代偿慢性心力衰的患者,住院期间使用参附注射液可显著增加患者对美托洛尔的耐受性,有利于神经激素阻断药物的积极使用,从而改善心力衰竭患者远期预后。从而更早、更积极的启动神经激素阻断治疗。

Objective To analyse the influence of Shen- fu injection on doses of metoprolol in patients with decompensated chronic heart failure. Methods Taking the hospitalized patients with decompensated chronic heart failure in acute attack as research object,dividing them into two groups,one is Shen- fu treatment group（ n = 30） and the other is control group（ n = 32）. According to metoprolol dose,mean arterial blood pressure,heart rate and serum creatinine between two groups,making an analysis about the influence of Shen- fu injection on the application of metoprolol. Results metoprolol ldose in Shen- fu treatment group was obviously higher than that of control group（ P〈0. 05）. While there was no significant impact on other indexes,such as mean arterial blood pressure,heart rate and serum creatinine（ P〉0. 05）. Conclusion The application of Shen- fu injection can remarkably increase metoprolol dose in hospitalized patients with decompensated chronic heart failure in acute attack,and there is no obvious effect on blood pressure,heart rate and renal function. Thus,the neurohormone interdict treatment can be applied more early and positively.