颈动脉斑块患者服用他汀药物对肾功能的影响

Effects of Stains on Renal Function in Patients with Carotid Artery Plaque

目的:探讨他汀类药物对颈动脉斑块患者肾功能的影响。方法:120例颈动脉斑块患者按服用他汀类药物种类随机分为4组,每组30例,A组阿托伐他汀10mg/d,B组辛伐他汀20mg/d,C组瑞舒伐他汀5mg/d,D组洛伐他汀20mg/d。测定治疗前后血脂、肾功能及高敏C反应蛋白(hs-CRP)。结果:服药4周及15周后,患者的总胆固醇、血甘油三酯、低密度脂蛋白胆固醇、胱抑素C、hsCRP水平较服药前明显降低(P<0.05),高密度脂蛋白胆固醇明显增高(P<0.05),尿素氮较服药前无明显降低(P>0.05);服药15周后,肌酐较服药前明显降低(P<0.05)。四组间比较差异无统计学意义(P>0.05)。结论:颈动脉斑块患者常规他汀类药物可降低血脂及炎症因子水平,对肾功能有保护作用。

Objective： To investigate the effects of statins on renal function in patients with plaque of carotid artery.Methods： 120 cases of patients with carotid atherosclerotic plaque by taking a statin drug kinds were randomly divided into 4 groups,30 cases in each group,a group of atorvastatin 10mg/d,simvastatin 20mg/d in group B,group C rosuvastatin cutting atorvastatin 5mg/d,D group lovastatin 20 mg.Determination of renal function and blood lipid and high sensitive C reactive protein（hs-CRP） before and after treatment.Results： Medication after 4 weeks and 15 weeks,serum total cholesterol,triglyceride,low density fat cholesterol,Cystatin C and hs-CRP levels than those before treatment decreased significantly（P〈0.05）,high density lipoprotein cholesterol was significantly higher（P〈0.05）,blood urea nitrogen（BUN） compared with those before taking no decreased significantly（P〈0.05）; after 15 weeks of dosing,creatinine than before treatment decreased significantly（P〈0.05）.There was no significant difference between the four groups（P〈0.05）.Conclusion： Carotid plaques in patients with conventional statins can reduce blood lipids and inflammatory factors,have protective effects on renal function.